Reactome | ANKLE2 is deacetylated by SIRT2

Schema > Reaction > Entries

ANKLE2 is deacetylated by SIRT2 Show undefined attributes

catalystActivity	[CatalystActivity:10306074] NAD-dependent protein deacetylase activity of SIRT2 [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10306076
displayName	ANKLE2 is deacetylated by SIRT2
eventOf	[Pathway:R-BTA-2995383] Initiation of Nuclear Envelope (NE) Reformation - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9667965] ANKLE2 binds PP2A - Bos taurus [Reaction:R-BTA-2995389] ANKLE2 binds VRK1,(VRK2) - Bos taurus
inferredFrom	[Reaction:R-HSA-9667952] ANKLE2 is deacetylated by SIRT2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-BTA-9667946] ANKLE2 [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
name	ANKLE2 is deacetylated by SIRT2
output	[SimpleEntity:R-ALL-9667956] 2'-O-acetyl-ADP-ribose [cytosol] [EntityWithAccessionedSequence:R-BTA-2529000] ANKLE2 [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-197277] NAM [cytosol]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9667952
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2995383] Initiation of Nuclear Envelope (NE) Reformation
(precedingEvent)	[Reaction:R-BTA-9667965] ANKLE2 binds PP2A [Reaction:R-BTA-2995389] ANKLE2 binds VRK1,(VRK2)
(inferredTo)	[Reaction:R-HSA-9667952] ANKLE2 is deacetylated by SIRT2