Reactome | Phosphorylation of IKK-beta by TAK1

Schema > Reaction > Entries

Phosphorylation of IKK-beta by TAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10262591] protein serine/threonine kinase activity of DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:activated TAK1 complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10262593
displayName	Phosphorylation of IKK-beta by TAK1
eventOf	[Pathway:R-BTA-2871837] FCERI mediated NF-kB activation - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2730876] Phosphorylation of IKK-beta by TAK1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-BTA-168113] CHUK:IKBKB:IKBKG [cytosol]
isInDisease	false
isInferred	true
name	Phosphorylation of IKK-beta by TAK1
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-BTA-202513] CHUK:p-S177,S181-IKBKB:IKBKG [cytosol]
precedingEvent	[BlackBoxEvent:R-BTA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Bos taurus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2730876
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2871837] FCERI mediated NF-kB activation
(inferredTo)	[Reaction:R-HSA-2730876] Phosphorylation of IKK-beta by TAK1