Reactome | IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Schema > Reaction > Entries

IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10245940
displayName	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
eventOf	[Pathway:R-BTA-1059683] Interleukin-6 signaling - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-1067659] Assembly of hexameric IL-6 receptor - Bos taurus
inferredFrom	[Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - Homo sapiens
input	[Complex:R-BTA-1067687] IL6:IL6R-2 [extracellular region] [Complex:R-BTA-1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane]
isInDisease	false
isInferred	true
name	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) IL6:sIL6R binds to JAKs:IL6RB (gp130)
output	[Complex:R-BTA-1067691] IL6:sIL6R:IL6RB:JAKs [plasma membrane]
precedingEvent	[Reaction:R-BTA-1067640] IL6 binds IL6R-2 - Bos taurus
regulatedBy	[NegativeRegulation:10245941] Negative regulation by 'IL6:IL6R-2:IL6ST-2 [extracellular region]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-1067651
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-BTA-1067659] Assembly of hexameric IL-6 receptor
(inferredTo)	[Reaction:R-HSA-1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

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