Reactome | Proteasomal cleavage of substrate

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Proteasomal cleavage of substrate Show undefined attributes

catalystActivity	[CatalystActivity:9980498] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10026371
displayName	Proteasomal cleavage of substrate
eventOf	[Pathway:R-RNO-983168] Antigen processing: Ubiquitination & Proteasome degradation - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) - Rattus norvegicus [BlackBoxEvent:R-RNO-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Rattus norvegicus [Reaction:R-RNO-983144] Transport of Antigen peptide in to ER - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-983150] Proteasomal cleavage of substrate - Homo sapiens
input	[OtherEntity:R-ALL-983123] K48polyUb-antigenic substrate [cytosol]
isInDisease	false
isInferred	true
name	Proteasomal cleavage of substrate
output	[SimpleEntity:R-ALL-8942986] L-amino acid [cytosol] [SimpleEntity:R-ALL-983032] oligopeptide fragment (8-16aa) [cytosol] [SimpleEntity:R-ALL-983036] precursor peptide fragment (>16 aa) [cytosol] [DefinedSet:R-RNO-113595] Ub [cytosol]
precedingEvent	[Reaction:R-RNO-983147] Release of E3 from polyubiquitinated substrate - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-983150
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[BlackBoxEvent:R-RNO-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) [Reaction:R-RNO-983144] Transport of Antigen peptide in to ER [BlackBoxEvent:R-RNO-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
(inferredTo)	[BlackBoxEvent:R-HSA-983150] Proteasomal cleavage of substrate