Co-methylation networks associated with cognition and structural brain development during adolescence

In the January 2025 issue of Frontiers in Genetics, Jensen et al. explored the relationship between DNA methylation patterns and adolescent brain development. By analyzing a cohort of adolescents aged 9 to 14, they identified co-methylation networks linked to cognitive improvements and structural brain changes. Pathway analysis using Reactome revealed that these networks are enriched in neuronal-related pathways, suggesting that epigenetic modifications play a significant role in the maturation of the adolescent brain.