RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection

In the August 2024 issue of PLoS One, Huang et al. used the Reactome database to analyze the pattern of RNA editing in cells in response to infection by SARS-CoV-2 and found that editing was highest in transcripts of genes related to immune response andcytokine production. Single cell transcriptomics showed that the Reactome Interferon signaling pathway is enriched in plasmacytoid B cells, B cells, and T cell subtypes during SARS-CoV-2 infection.