In their May 2024 paper in Cell Genomics, Arora et al. used a framework of Reactome signaling and metabolism pathways to integrate RHEA metabolic reactions and IUPhAR catalogs of G Protein-Coupled Receptors (GPCRs) and their ligands to define axes that combine signaling cascades and ligand metabolic processes. Altered expression of the sets of proteins that make up these axes correlate with patient survival cataloged in The Cancer Genome Atlas (TCGA) for many tumor types and suggest novel druggable targets.