Identification of potential biological processes and key genes in diabetes-related stroke through weighted gene co-expression network analysis

Using WGCNA, GO and KEGG data analysis tools, He Y et al. in the January 2024 issue of BMC Medical Genomics, established a connection among the genes and pathways associated with type 2 diabetes (T2D) and ischemic stroke (IS) and identified GRN (granulin precursor) as the hub gene in T2D-related stroke. The functional enrichment analysis using Reactome analysis tool for GRN identified Neutrophil degranulation, Toll-like Receptor Cascades, DDX58/IFIH1-mediated induction of interferon-alpha/ beta, and NLR signaling pathways as shared biological processes in T2D and IS.