In the July 2023 issue of BMB Reports, Lee et al. (2023) employed the Reactome pathway database and tools to predict the anti-cancer effects of rutin, a natural phytochemical identified as a lead chemotherapeutic against breast cancer by text mining Korean traditional medicinal compendia from 1596 CE and 1613 CE. Genes that may be associated with rutin's effects were analyzed for pathway enrichment and functional interactions by the Reactome Functional Interaction (FI) plugin app of Cytoscape. Focal adhesion and Apoptosis were among the pathways predicted to be affected by rutin and these effects were confirmed by treatment of breast cancer cells with rutin in vitro and in xenografts in mice.