Using Reactome analysis tools and FIVIz, Balmorez et al. in the March 2023 issue of Int. J. Mol. Sci., established a commonality between the genes and pathways associated with Alzheimer's disease (AD), Ageing (AR) and Longevity. The pathways shared between AD and AR are p53-Dependent G1/S DNA damage checkpoint, FOXO-mediated transcription, and SUMOylation; between AD and longevity are Cytokine Signaling in Immune system, Plasma lipoprotein assembly, remodeling, and clearance, Metabolism of fat-soluble vitamins, and NR1H2- and NR1H3-mediated signalling; and between AR and Longevity are Immune system and Cytokine signaling.