Gene set enrichment analysis (GSEA) conducted on Reactome’s carbohydrate metabolism pathways identifies the Pentose phosphate pathway and the Glucose metabolism pathway as the two most frequently upregulated pathways in tumors with high tumor-specific total mRNA expression (TmS) across 15 tumor types; TmS is a novel tumor phenotype-predictive quantitative feature described by Cao et al. in the November 2022 issue of Nature Biotechnology.