Search results for Q9NRF2
Showing 3 results out of 3
Results (3 results from a total of 3)
Identifier: R-HSA-1675482
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SH2B1:
Q9NRF2
Identifier: R-HSA-997253
Species:
Homo sapiens
Compartment:
cytosol
Primary external reference: UniProt: SH2B1:
Q9NRF2
Identifier: R-HSA-1675473
Species:
Homo sapiens
Compartment:
plasma membrane,
cytosol
The SH2 domains of SH2B beta (Uniprot isoform Q9NRF2-2) binds JAK2 at Tyr813. SH2B beta is able to homodimerize while bound to JAK2 molecules, suggesting that SH2B binding and dimerization may help induce JAK2 transactivation (Nishi et al. 2005). Computational modeling suggests that SH2B beta can enhance Jak2 activation (Barua et al. 2009). The relevance of this for PRLR signalling has yet to be demonstrated.
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