Search results for ID1 ID2 ID3 ID4

Showing 30 results out of 61

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Results (30 results from a total of 61)

ID4

Identifier: R-HSA-3701048
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ID4: P47928

ID3

Identifier: R-HSA-9613379
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ID3: Q02535
Identifier: R-HSA-9613460
Species: Homo sapiens
Compartment: nucleoplasm
ID1-4 (Inhibitor of DNA-binding) are members of the helix-loop-helix family of proteins that lack the basic amino acids responsible for DNA binding in basic HLH proteins. HLH domain-mediated heterodimerization of an ID protein with a basic HLH protein therefore acts as a natural dominant negative inhibitor of bHLH function by preventing DNA binding (Massari and Murre, 2000). ID proteins primarily interact with members of the E family of proteins, including E12, E47, HEB and E2-2, but also interact with other bHLH proteins. ID proteins promote cell cycle progression and cell migration, and restrict cellular senescence and the differentiation of a number of progenitor cell types, including oligodendrocytes (reviewed in Perk et al, 2005; Ling et al, 2014). ID1 and ID3 proteins also have established roles in hematopoiesis (Nogueira et al, 2000; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016).
ID1 and ID3 gene expression is activated by the binding of CREB1 to CRE sites in the promoter. CREB recruits transcriptional co-activators p300 and CBP in a CREB S133 phosphorylation-dependent manner (reviewed in Shaywitz and Greenberg, 1999). ID1 and ID3 gene activation also depends on the CREB1-dependent recruitment of LYL1, a basic helix-loop-helix transcription factor with roles in cell proliferation and differentiation. The N-terminal domain of LYL1 interacts with the Q2 and KID domains of CREB1 in a manner that does not require CREB1 S133 phosphorylation (San Marina et al, 2008).

ID2

Identifier: R-HSA-452391
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ID2: Q02363
Identifier: R-HSA-9612533
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9613456
Species: Homo sapiens
Compartment: nucleoplasm

ID1

Identifier: R-HSA-2534101
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: UniProt: ID1: P41134

ID2

Identifier: P41136
Species: Mus musculus
Primary external reference: UniProt: P41136
Identifier: R-HSA-9612534
Species: Homo sapiens
Compartment: nucleoplasm
ID1-4 (Inhibitor of DNA-binding) are members of the helix-loop-helix family of proteins that lack the basic amino acids responsible for DNA binding in basic HLH proteins. HLH domain-mediated heterodimerization of an ID protein with a basic HLH protein therefore acts as a natural dominant negative inhibitor of bHLH function by preventing DNA binding (Massari and Murre, 2000). ID proteins primarily interact with members of the E family of proteins, including E12, E47, HEB and E2-2, but also interact with other bHLH proteins. ID proteins promote cell cycle progression and cell migration, and restrict cellular senescence and the differentiation of a number of progenitor cell types, including oligodendrocytes (reviewed in Perk et al, 2005; Ling et al, 2014). Expression of ID2 and ID4 is negatively regulated by an EGR2:NAB2 complex that is recruited to the EGR binding sites in the promoter. Repression of ID2 and ID4 during development is associated with increased promoter occupancy of the EGR2:NAB2 complex and may be effected through the recruitment of the NURD chromatin remodelling complex and histone deacetylases. NAB2 has been shown to interact with the CHD4 and CHD3 subunits of the NURD complex through its conserved CHD4-interacting domain (CID) (Mager et al, 2008; Srinivasan et al, 2006; Hung et al, 2012).

ID1

Identifier: R-BTA-2534101
Species: Bos taurus
Compartment: nucleoplasm
Primary external reference: UniProt: A4IF68

ID1

Identifier: R-CFA-2534101
Species: Canis familiaris
Compartment: nucleoplasm
Primary external reference: UniProt: E2RB72

id1

Identifier: R-DRE-2534101
Species: Danio rerio
Compartment: nucleoplasm
Primary external reference: UniProt: Q6IQW5

Id1

Identifier: R-RNO-2534101
Species: Rattus norvegicus
Compartment: nucleoplasm
Primary external reference: UniProt: P41135

Id1

Identifier: R-MMU-2534101
Species: Mus musculus
Compartment: nucleoplasm
Primary external reference: UniProt: P20067

Id1

Identifier: R-GGA-2534101
Species: Gallus gallus
Compartment: nucleoplasm
Primary external reference: UniProt: Q90X15

ID1

Identifier: R-SSC-2534101
Species: Sus scrofa
Compartment: nucleoplasm
Primary external reference: UniProt: B3W6M6
Identifier: R-HSA-9612537
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9613449
Species: Homo sapiens
Compartment: nucleoplasm
Identifier: R-HSA-9613476
Species: Homo sapiens
Compartment: nucleoplasm
EGR2 is required for peripheral nerve cell myelination in Schwann cells where it activates some target genes and represses others (Topilko et al, 1999; Zorick et al, 1996; Le et al, 2005; Le Blanc et al, 2005). ID2 and ID4 were identified as targets of EGR2-mediated repression during peripheral nerve myelination (Mager et al, 2008). EGR2 represses ID2 and ID4 gene expression by recruiting NAB2 and the NURD chromatin remodelling complex (Mager et al, 2008, Srinivasan et al, 2006).
Identifier: R-HSA-3701033
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000172201
Identifier: R-HSA-9613376
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000117318
Identifier: R-HSA-9612536
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000115738
Identifier: R-HSA-9613373
Species: Homo sapiens
Compartment: nucleoplasm
Primary external reference: ENSEMBL: ENSG00000125968
Identifier: R-HSA-9613451
Species: Homo sapiens
Compartment: nucleoplasm
CREB1, EP300 and LYL1 are required for the activation of the ID1 and ID3 genes, which contribute to cellular proliferation and differentiation (Impey et al, 2004; San Marina et al, 2008; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016). CREB1 binds to the CRE elements in the ID gene promoters and recruits EP300 in a CREB1 S133 phosphorylation dependent manner. S133 phosphorylation is dispensable for recruitment of LYL1, which instead depends on an interaction between the LYL1 N-terminal domain and the Q2 and KID domains of CREB1 (San Marina et al, 2008).
Identifier: R-HSA-3209165
Species: Homo sapiens
Compartment: nucleoplasm
Binding of ID1 to ETS2 inhibits ETS2-mediated activation of p16INK4A transcription (Ohtani et al. 2001).
Identifier: R-CFA-3209165
Species: Canis familiaris
Compartment: nucleoplasm
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-MMU-3209165
Species: Mus musculus
Compartment: nucleoplasm
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-RNO-3209165
Species: Rattus norvegicus
Compartment: nucleoplasm
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-SSC-3209165
Species: Sus scrofa
Compartment: nucleoplasm
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-DRE-3209165
Species: Danio rerio
Compartment: nucleoplasm
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

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