Search results for 0030060

Showing 30 results out of 53

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Protein (15 results from a total of 24)

Identifier: R-HSA-198471
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: MDH1: P40925
Identifier: R-HSA-977340
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: PHGDH: O43175
Identifier: R-MMU-198471
Species: Mus musculus
Compartment: cytosol
Primary external reference: UniProt: P14152
Identifier: R-DME-198471
Species: Drosophila melanogaster
Compartment: cytosol
Primary external reference: UniProt: Q9VKX2
Identifier: R-CFA-198471
Species: Canis familiaris
Compartment: cytosol
Primary external reference: UniProt: A0A8I3P822
Identifier: R-RNO-198471
Species: Rattus norvegicus
Compartment: cytosol
Primary external reference: UniProt: O88989
Identifier: R-XTR-198471
Species: Xenopus tropicalis
Compartment: cytosol
Primary external reference: UniProt: Q6DIY9
Identifier: R-SSC-198471
Species: Sus scrofa
Compartment: cytosol
Primary external reference: UniProt: P11708
Identifier: R-CEL-198471
Species: Caenorhabditis elegans
Compartment: cytosol
Primary external reference: UniProt: Q9UAV5
Identifier: R-BTA-198471
Species: Bos taurus
Compartment: cytosol
Primary external reference: UniProt: Q3T145
Identifier: R-GGA-372856
Species: Gallus gallus
Compartment: cytosol
Primary external reference: UniProt: MDH1: Q5ZME2
Identifier: R-GGA-372414
Species: Gallus gallus
Compartment: mitochondrial matrix
Primary external reference: UniProt: E1BVT3
Identifier: R-HSA-70977
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: MDH2: P40926
Identifier: R-MMU-70977
Species: Mus musculus
Compartment: mitochondrial matrix
Primary external reference: UniProt: P08249
Identifier: R-SCE-70977
Species: Saccharomyces cerevisiae
Compartment: mitochondrial matrix
Primary external reference: UniProt: P22133

Reaction (15 results from a total of 29)

Identifier: R-HSA-70979
Species: Homo sapiens
Compartment: mitochondrial matrix
Mitochondrial malate dehydrogenase (MDH2) dimer catalyzes the reversible reaction of malate and NAD+ to form oxaloacetate (OA) and NADH + H+ (Luo et al. 2006; Eo et al., 2022). This reaction is highly endergonic but is pulled in the direction annotated here when the TCA cycle is operating. The active enzyme is a palmitoylated homodimer (Sanchez et al. 1998; Pei et al., 2022). Mutations in MDH2 can cause infantile epileptic encephalopathy (DEE51, MIM:617339; see Priestley et al., 2022).
Identifier: R-HSA-9856871
Species: Homo sapiens
Compartment: cytosol
Cytosolic MDH1 (malate dehydrogenase 1) catalyzes the reversible reaction of oxaloacetate (OA) and NADH + H+ to form malate (MAL) and NAD+ (Friedrich et al. 1988; Lo et al. 2005). This reaction provides the malate-aspartate shuttle with reducing equivalents that are transported in the form of MAL into the mitochondrion, and are available there as NADH from the reverse reaction catalyzed by MDH2. Sources of cytosolic NADH are glycolysis, serine biosynthesis, and peroxisomal fatty acid oxidation (reviewed by Borst, 2020). The dimeric structure of the human dehydrogenase is inferred from human and pig crystallographic data (McCue & Finzel, 2021; Birktoft et al. 1989). Mutations in MDH1 can cause a form of early-onset epileptic encephalopathy (DEE88, MIM:618959; Broeks et al., 2019).
Identifier: R-MMU-70979
Species: Mus musculus
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-MMU-9856871
Species: Mus musculus
Compartment: cytosol
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-RNO-9856871
Species: Rattus norvegicus
Compartment: cytosol
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-RNO-70979
Species: Rattus norvegicus
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-CFA-70979
Species: Canis familiaris
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-CFA-9856871
Species: Canis familiaris
Compartment: cytosol
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-BTA-70979
Species: Bos taurus
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-SSC-70979
Species: Sus scrofa
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-SSC-9856871
Species: Sus scrofa
Compartment: cytosol
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-DRE-70979
Species: Danio rerio
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-DME-70979
Species: Drosophila melanogaster
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-BTA-9856871
Species: Bos taurus
Compartment: cytosol
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Identifier: R-XTR-70979
Species: Xenopus tropicalis
Compartment: mitochondrial matrix
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

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