<<< Go back

Marc E Gillespie

 ORCID
https://orcid.org/0000-0002-5766-1702
Project
Reactome
Affiliation
Cold Spring Harbor Laboratory, St. John's University, NYU School of Medicine, Department of Biochemistry
Reviewed Reactions (383)
Date Identifier Reaction Reference
2020-01-03 R-HSA-163096 Recruitment of Telomerase RNP to the Telomeric Chromosome End BibTex
2020-01-03 R-HSA-174447 RFC dissociates after sliding clamp formation on the C-strand of the telomere BibTex
2020-01-03 R-HSA-174452 RFC binding displaces Pol Alpha on the C-strand of the telomere BibTex
2019-06-03 R-HSA-9645442 Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex BibTex
2019-06-03 R-HSA-9645406 ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) BibTex
2019-06-03 R-HSA-9645394 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation BibTex
2019-06-03 R-HSA-9645414 Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer BibTex
2019-06-03 R-HSA-9645501 TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex BibTex
2019-06-03 R-HSA-9645520 ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 BibTex
2019-06-03 R-HSA-9645481 TIFA oligomerization BibTex
2019-06-03 R-HSA-9645535 ALPK1 phosphorylates TIFA BibTex
2019-06-03 R-HSA-9645524 ALPK1:ADP-heptose binds TIFA BibTex
2019-06-03 R-HSA-9645428 ALPK1 binds ADP-heptose BibTex
2018-07-28 R-RNO-9614351 Unblocking of Grin1:Grin2 NMDA receptors BibTex
2018-07-28 R-RNO-9614350 Glycine and glutamate ligands bind Grin1:Grin2a NMDA receptor BibTex
2018-07-28 R-HSA-9614185 Mg2+ binds GRIN1:GRIN2 NMDA receptors BibTex
2018-07-28 R-RNO-9614228 Mg2+ binds Grin1:Grin2 NMDA receptors BibTex
2016-02-02 R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane BibTex
2016-02-02 R-HSA-8847883 CYTH proteins stimulate ARF1 GTPase activity BibTex
2016-02-02 R-HSA-8847880 CYTH proteins bind ARF1:GTP BibTex
2016-02-02 R-HSA-8847887 RAB33B:GTP binds RIC1:RGP1 BibTex
2016-02-02 R-HSA-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN BibTex
2016-02-02 R-HSA-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange BibTex
2016-02-02 R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles BibTex
2016-02-02 R-SCE-6814089 NatC acetylates ARL3 BibTex
2016-02-02 R-HSA-6814090 NatC acetylates ARFFRP1 BibTex
2016-02-02 R-HSA-6814088 SYS1 binds AcM-ARFRP1 BibTex
2016-02-02 R-HSA-6814086 ARFRP1 recruits ARL1 to the TGN BibTex
2016-02-02 R-HSA-6814675 RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN BibTex
2016-02-02 R-HSA-6814670 ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation BibTex
2016-02-02 R-HSA-6814674 Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins BibTex
2016-02-02 R-HSA-6814671 Fusion of late-endosome derived vesicles at the TGN BibTex
2016-02-02 R-HSA-6814094 ARL1:GTP binds ARFIP2 BibTex
2016-02-02 R-HSA-8847537 RAB43:GTP binds USP8NL BibTex
2016-02-02 R-HSA-8847534 RAB43 hydrolyses GTP BibTex
2016-02-02 R-HSA-6814091 ARL1 recruits TGN Golgin homodimers BibTex
2016-02-02 R-HSA-6814676 SNAPs and NSF hexamer bind cis-SNARE at the TGN BibTex
2016-02-02 R-HSA-6814678 ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN BibTex
2016-02-02 R-HSA-6814096 ARL1:GTP binds SCOC BibTex
2016-02-02 R-HSA-6814682 Fusion of early-endosome derived vesicles at the TGN BibTex
2016-02-02 R-HSA-6814684 cis-SNARE binds SNAPs and NSF hexamer at the TGN BibTex
2016-02-02 R-HSA-6814683 NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN BibTex
2016-02-02 R-HSA-8849348 RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo BibTex
2016-02-02 R-HSA-8849350 RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex BibTex
2016-02-02 R-HSA-8848484 PLA2s hydrolyze phospholipids at the Golgi membrane BibTex
2016-02-02 R-HSA-8849345 LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine BibTex
2016-02-02 R-HSA-8849353 Dynein drives COPI-independent retrograde traffic from the Golgi to the ER BibTex
2016-02-02 R-HSA-8850040 RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER BibTex
2016-02-02 R-HSA-8850041 RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18 BibTex
2016-02-02 R-HSA-6811415 RAB:GTP recruits GBF1 to the Golgi membrane BibTex
2016-02-02 R-HSA-6811411 GBF1 recruits ARF:GDP to the Golgi BibTex
2016-02-02 R-HSA-6811414 GBF1 stimulates nucleotide exchange on ARF BibTex
2016-02-02 R-HSA-6811412 Active ARF recruits coatomer to the Golgi BibTex
2016-02-02 R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi BibTex
2016-02-02 R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane BibTex
2016-02-02 R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules BibTex
2016-02-02 R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs BibTex
2016-02-02 R-HSA-6811427 COPI vesicle uncoating at the ER BibTex
2016-02-02 R-HSA-6811425 NSF and SNAPs bind cis-SNARE at the ER membrane BibTex
2016-02-02 R-HSA-6811422 NSF ATPase activity dissociates cis-SNARE at the ER BibTex
2016-02-02 R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering BibTex
2016-02-02 R-HSA-8847635 Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic BibTex
2016-02-02 R-HSA-8847637 NSF and SNAPs bind the cis-SNARE at the Golgi BibTex
2016-02-02 R-HSA-8847638 ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane BibTex
2016-02-02 R-HSA-8849748 The COG complex binds RABs at the Golgi membrane BibTex
2016-02-02 R-HSA-8847875 ARF1:GTP binds Golgin TRIP11 BibTex
2015-11-25 R-HSA-6814833 TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP BibTex
2015-11-25 R-HSA-6814831 TBC1D20 binds RAB1:GTP BibTex
2015-09-02 R-HSA-6809015 NSF ATPase activity dissociates cis-SNARE at cis-Golgi BibTex
2015-09-02 R-HSA-6809014 cis-Golgi cis-SNARE binds NSF and SNAPs BibTex
2015-09-02 R-HSA-6809010 COPI vesicle uncoating BibTex
2015-09-02 R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle BibTex
2015-09-02 R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex BibTex
2015-09-02 R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin BibTex
2015-09-02 R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity BibTex
2015-09-02 R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex BibTex
2015-09-02 R-HSA-6807872 Active ARF recruits coatomer BibTex
2015-09-02 R-HSA-6807868 GBF1 stimulates ARF nucleotide exchange BibTex
2015-09-02 R-HSA-6807866 GBF1 recruits ARF:GDP to the ERGIC BibTex
2015-09-02 R-HSA-6807864 RAB1:GTP recruits GBF1 to the ERGIC BibTex
2015-08-18 R-HSA-5694421 PP6 dephosphorylates SEC24 BibTex
2015-08-18 R-HSA-5694427 MIA3 binds procollagen VII BibTex
2015-08-18 R-HSA-5694410 TMED2:TMED10 tetramer binds GPI anchored proteins BibTex
2015-08-18 R-HSA-5694445 CNIH1 binds TFGA and AREG precursors BibTex
2015-08-18 R-HSA-5694413 SEC4C,D bind GOSR2 and STX5 BibTex
2015-08-18 R-HSA-5694431 Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors BibTex
2015-08-18 R-HSA-5694415 SEC24A,B:SEC23A bind SEC22B BibTex
2015-08-18 R-HSA-5694435 MIA2 and MIA3 load procollagen VII into COPII vesicles BibTex
2015-08-18 R-HSA-5694436 MIA2 and MIA3 dissociate from procollagen VII vesicle BibTex
2015-08-18 R-HSA-5694428 LMAN family proteins bind glycosylated cargo BibTex
2015-08-18 R-HSA-5694433 MIA2 binds PREB BibTex
2015-08-18 R-HSA-5694442 CNIH2,3 bind GRIA1 BibTex
2015-08-18 R-HSA-5694425 NSF ATPase activity dissociates cis-SNARE BibTex
2015-08-18 R-HSA-5694423 NSF and SNAPs bind cis-SNARE complex BibTex
2015-08-18 R-HSA-5694446 BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle BibTex
2015-08-18 R-HSA-5694441 CSNK1D phosphorylates SEC23 BibTex
2015-08-18 R-HSA-5694418 RAB1:GTP binds USO1 and GORASP1:GOLGA2 BibTex
2015-08-18 R-HSA-5694409 Nucleotide exchange on RAB1 BibTex
2015-08-18 R-HSA-5694439 COPII coat binds TRAPPCII and RAB1:GDP BibTex
2015-08-18 R-HSA-5694417 SEC16 complex binds SAR1B:GTP:SEC23:SEC24 BibTex
2015-08-18 R-HSA-5694522 Inner coat assembly and cargo binding BibTex
2015-03-12 R-HSA-5626981 TNF-alpha:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 BibTex
2015-03-12 R-HSA-5626982 TNF-alpha:TNFR1:NSMAF binds GNB2L1 BibTex
2015-03-12 R-HSA-5626988 TNF-alpha:TNFR1 binds NSMAF BibTex
2015-03-12 R-HSA-5357860 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex BibTex
2015-03-12 R-HSA-5357776 TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG BibTex
2015-03-12 R-HSA-5357904 TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC BibTex
2015-03-12 R-HSA-5626953 TNF-alpha:TNFR1 binds DENN/MADD BibTex
2015-03-12 R-HSA-5661517 LUBAC comlex binds OTULIN BibTex
2015-03-12 R-HSA-5357928 CLIP3 and CYLD bind TNF signaling complex BibTex
2015-03-12 R-HSA-5634221 TRAF1 binds TRAF2 within TNFR1 signaling complex BibTex
2015-03-12 R-HSA-5357831 CYLD is phosphorylated by IKK BibTex
2015-03-12 R-HSA-5692550 Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 BibTex
2015-03-12 R-HSA-5626962 GNB2L1 binds IKKA:IKKB:NEMO BibTex
2015-03-12 R-HSA-5357845 RIPK1 is deubiquitinated BibTex
2015-03-12 R-HSA-5357757 BIRC(cIAP1/2) ubiquitinates RIPK1 BibTex
2015-03-12 R-HSA-5357780 TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) BibTex
2015-03-12 R-HSA-5634228 TRAF1 is cleaved by caspases BibTex
2015-03-12 R-HSA-5357828 RIPK1 is cleaved by CASP8 BibTex
2015-02-06 R-HSA-112124 Oxidative demethylation of 3-meC damaged DNA By ALKBH3 BibTex
2015-02-06 R-HSA-112125 Oxidative dealkylation of 1-EtA damaged DNA by ABH3 BibTex
2015-02-06 R-HSA-5657642 ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA BibTex
2015-02-06 R-HSA-112123 Oxidative demethylation of 1-meA damaged DNA By ALKBH3 BibTex
2015-02-06 R-HSA-5657617 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC BibTex
2015-02-06 R-HSA-5657637 ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA BibTex
2015-02-06 R-HSA-112120 Oxidative demethylation of 3-meC damaged DNA by ALKBH2 BibTex
2015-02-06 R-HSA-112121 Oxidative dealkylation of 1-etA damaged DNA By ALKBH2 BibTex
2015-02-06 R-HSA-5657649 ALKBH2 binds alkylated DNA containing 1-etA BibTex
2015-02-06 R-HSA-5657665 ALKBH2 binds alkylated dsDNA containing 3-meC BibTex
2015-02-06 R-HSA-112118 Oxidative demethylation of 1-meA damaged DNA by ALKBH2 BibTex
2015-02-06 R-HSA-5657641 ALKBH2 binds alkylated DNA containing 1-meA BibTex
2015-02-06 R-HSA-73892 MGMT/hAGT mediated DNA Damage Reversal BibTex
2015-02-06 R-HSA-5657651 MGMT binds alkylated DNA containing 6-O-methylguanine BibTex
2014-10-31 R-HSA-5213462 RIPK3 binds RIPK1 BibTex
2014-10-31 R-HSA-5213466 RIPK3 is phosphorylated BibTex
2014-10-31 R-HSA-5213464 RIPK1 is phosphorylated BibTex
2014-10-31 R-HSA-5218905 RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils BibTex
2014-10-31 R-HSA-5218891 RIPK1:RIPK3 oligomer binds MLKL BibTex
2014-10-31 R-HSA-5218906 RIPK3 phosphorylates MLKL BibTex
2014-10-31 R-HSA-5357927 MLKL oligomerizes BibTex
2014-10-31 R-HSA-5620975 MLKL binds PIPs BibTex
2012-12-20 R-HSA-202724 P-selectin binds P-selectin ligand BibTex
2012-12-20 R-HSA-2870221 E-selectin binds E-selectin ligand BibTex
2012-11-19 R-HSA-351863 Translocation of active caspase-8 to the mitochondrial membrane BibTex
2012-11-19 R-HSA-139952 Caspase-8 processing in the DISC BibTex
2012-11-19 R-HSA-73945 FAS-mediated dimerization of procaspase-8 BibTex
2012-11-19 R-HSA-141156 TRAIL-mediated dimerization of procaspase-8 BibTex
2012-11-19 R-HSA-141159 TNF-mediated dimerization of procaspase-8 BibTex
2012-02-09 R-HSA-1679589 Engulfed CpG DNA binds to endosomal full-length TLR9 BibTex
2012-02-09 R-HSA-1679098 Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer BibTex
2012-02-09 R-HSA-1678981 TLR9 processing at neutral pH BibTex
2012-02-09 R-HSA-1678920 TLR processing at low pH BibTex
2012-02-09 R-HSA-1678927 UNC93B1 delivers endosomal full-length TLRs to endolysosome BibTex
2012-02-09 R-HSA-1678998 Endosomal TLRs pass through the Golgi BibTex
2012-02-09 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 BibTex
2012-02-09 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex BibTex
2012-02-09 R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 BibTex
2011-02-10 R-HSA-975879 Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex BibTex
2011-02-10 R-HSA-975857 TRAF6 binds to hp- IRAK1 or p-IRAK2 BibTex
2011-02-10 R-HSA-975861 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex BibTex
2011-02-10 R-HSA-975853 Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR BibTex
2011-02-10 R-HSA-975874 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex BibTex
2011-02-10 R-HSA-975878 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR BibTex
2011-02-10 R-HSA-975852 IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex BibTex
2011-02-10 R-HSA-975865 IRAK4 autophosphorylation within the complex activated TLR:MyD88 BibTex
2011-02-10 R-HSA-975873 IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor BibTex
2011-02-10 R-HSA-975880 MyD88 oligomerization within the complex of activated TLR:MyD88 BibTex
2011-02-10 R-HSA-975866 MyD88 forms a complex with the activated TLR receptor BibTex
2011-02-10 R-HSA-188025 Flagellin binds to TLR5 BibTex
2011-02-10 R-HSA-168947 Ligand binds to TLR10 BibTex
2010-11-30 R-HSA-9014342 K63-linked ubiquitination of RIP1 bound to the activated TLR complex BibTex
2010-11-30 R-HSA-9014343 IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex BibTex
2010-11-30 R-HSA-9013978 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex BibTex
2010-11-30 R-HSA-9013979 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3 BibTex
2010-11-30 R-HSA-9013986 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation BibTex
2010-11-30 R-HSA-166168 TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) BibTex
2010-11-30 R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex BibTex
2010-11-30 R-HSA-2559464 TLR6/2 ligand associates with CD14 and CD36 within lipid rafts BibTex
2010-11-30 R-HSA-168950 TLR6:TLR2 is recruited to ligand:CD14:CD36 BibTex
2010-11-30 R-HSA-168951 TLR1:TLR2 is recruited to ligand:CD14 BibTex
2010-11-30 R-HSA-166015 Association of LBP with LPS BibTex
2010-11-30 R-HSA-166038 GPI-bound CD14 binds LPS BibTex
2010-11-30 R-HSA-169719 Secreted CD14 binds LPS BibTex
2010-11-30 R-HSA-166041 Transfer of LPS onto TLR4 BibTex
2010-11-30 R-HSA-166072 MyD88 forms a complex with TIRAP:activated TLR2/4 BibTex
2010-11-30 R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 BibTex
2010-11-30 R-HSA-166082 IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex BibTex
2010-11-30 R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP BibTex
2010-11-30 R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex BibTex
2010-11-30 R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal BibTex
2010-11-30 R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP BibTex
2010-11-30 R-HSA-166286 Multiple IRAK1 autophosphorylation steps BibTex
2010-11-30 R-HSA-166363 TRAF6 binds to hp- IRAK1 BibTex
2010-11-30 R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex BibTex
2010-11-30 R-HSA-936963 IRAK2 induces TRAF6 oligomerization BibTex
2010-11-30 R-HSA-936942 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 BibTex
2010-11-30 R-HSA-936986 Activated TRAF6 synthesizes unanchored polyubiquitin chains BibTex
2010-11-30 R-HSA-936960 Activated TRAF6:p-IRAK2 interacts with TAK1 complex BibTex
2010-11-30 R-HSA-936991 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 BibTex
2010-11-30 R-HSA-166175 TRAM:TLR4:LY96:LPS:CD14 recruits TRIF (TICAM1) BibTex
2010-11-30 R-HSA-936985 Activated TLR4:TICAM1 recruits TRAF6 BibTex
2010-11-30 R-HSA-936952 Auto ubiquitination of TRAF6 bound to the activated TLR4 complex BibTex
2010-11-30 R-HSA-936947 Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex BibTex
2010-11-30 R-HSA-936951 Activation of TAK1 complex bound to activated TLR4 complex BibTex
2010-11-30 R-HSA-168921 TRIF:activated TLR3/TLR4 complex recruits RIP1 BibTex
2010-11-30 R-HSA-168915 K63-linked ubiquitination of RIP1 bound to the activated TLR complex BibTex
2010-11-30 R-HSA-937029 IKBKG subunit of IKK complex binds polyubiquinated RIP1 BibTex
2010-11-30 R-HSA-936941 Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation BibTex
2010-11-30 R-HSA-166271 IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 BibTex
2010-11-30 R-HSA-166245 Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex BibTex
2010-11-30 R-HSA-168933 Dimerization of phosphorylated IRF3/IRF7 BibTex
2010-11-30 R-HSA-177671 Dimerized phospho-IRF3/IRF7 is transported to the nucleus BibTex
2010-11-30 R-HSA-937075 Phosphorylated TAK1 leaves activated TLR receptor complex BibTex
2010-11-30 R-HSA-937044 Pellino binds hp-IRAK1:TRAF6 BibTex
2010-11-30 R-HSA-937034 IRAK1 phosphorylates Pellino BibTex
2010-11-30 R-HSA-937050 Pellino ubiquitinates hp-IRAK1 BibTex
2010-11-30 R-HSA-937032 NEMO subunit of IKK complex binds to activated IRAK1 BibTex
2010-11-30 R-HSA-166869 TRAF6 binds MEKK1 BibTex
2010-11-30 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex BibTex
2010-11-30 R-HSA-2262777 TRAF6 binds to p-IRAK2 BibTex
2010-11-24 R-HSA-109864 Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 BibTex
2010-11-24 R-HSA-109863 Dissociation of p-T,Y-MAPK3:MAP2K1 BibTex
2010-10-29 R-HSA-975119 NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9. BibTex
2010-10-29 R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
BibTex
2010-10-29 R-HSA-975139 IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation BibTex
2010-10-29 R-HSA-975142 Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation BibTex
2010-10-29 R-HSA-975103 Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation BibTex
2010-10-29 R-HSA-975097 Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation BibTex
2010-10-29 R-HSA-975118 TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex BibTex
2010-10-29 R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation BibTex
2010-10-29 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation BibTex
2010-10-29 R-HSA-975147 Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane BibTex
2010-10-29 R-HSA-975185 IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments BibTex
2010-10-29 R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex BibTex
2010-10-29 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 BibTex
2010-10-29 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 BibTex
2010-10-29 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 BibTex
2010-10-29 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 BibTex
2010-10-29 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 BibTex
2010-10-29 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. BibTex
2010-10-29 R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 BibTex
2010-10-29 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex BibTex
2010-10-29 R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 BibTex
2010-10-29 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 BibTex
2010-05-28 R-HSA-847070 Phosphorylated TAK1 dissociates from the TLR3 receptor complex BibTex
2010-03-02 R-HSA-450358 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation BibTex
2010-03-02 R-HSA-9628444 Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation BibTex
2010-03-02 R-HSA-450259 Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex BibTex
2010-02-28 R-HSA-450257 Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 BibTex
2010-02-28 R-HSA-450222 Active p38 MAPK phosphorylates MAPKAPK2 or 3 BibTex
2010-02-28 R-HSA-450325 c-FOS activation by phospho ERK1/2 BibTex
2010-02-28 R-HSA-450333 Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 BibTex
2010-02-28 R-HSA-450296 Phosphorylated MKK3/MKK6 migrates to nucleus BibTex
2010-02-28 R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6 BibTex
2010-02-28 R-HSA-450348 Activated human JNKs migrate to nucleoplasm BibTex
2010-02-28 R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7 BibTex
2009-06-02 R-HSA-265645 Calcium Influx through Voltage-gated Calcium Channels BibTex
2009-06-02 R-HSA-381727 RAP1A exchanges GDP for GTP BibTex
2009-06-02 R-HSA-381608 cAMP activates EPAC2 BibTex
2009-06-02 R-HSA-381644 ER calcium channels open in response to activated PKA BibTex
2009-06-02 R-HSA-381713 Potassium voltage-gated channels close in reponse to PKA BibTex
2009-06-02 R-HSA-381668 cAMP activates EPAC1 BibTex
2009-06-02 R-HSA-265682 KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel BibTex
2009-06-02 R-HSA-381707 PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP BibTex
2009-06-02 R-HSA-381607 Activated Adenylyl cyclase synthesizes cyclic AMP BibTex
2009-06-02 R-HSA-381704 G(s):GTP activates Adenylyl cyclase BibTex
2009-06-02 R-HSA-381706 GLP1R:GLP1 activates G(s) BibTex
2009-06-02 R-HSA-381612 GLP1R binds GLP1 BibTex
2009-06-02 R-HSA-399978 Protein kinase C, alpha type phosphorylates MARCKS BibTex
2009-06-02 R-HSA-265166 Exocytosis of Insulin BibTex
2009-06-02 R-HSA-400015 Diacylgycerol activates Protein kinase C, alpha type BibTex
2009-06-02 R-HSA-169683 IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol BibTex
2009-06-02 R-HSA-169680 IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel BibTex
2009-06-02 R-HSA-399998 Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate BibTex
2009-06-02 R-HSA-400023 Gq alpha activates Phospholipase C beta BibTex
2009-06-02 R-HSA-400027 Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma BibTex
2009-06-02 R-HSA-399995 Muscarinic Acetylcholine Receptor M3 activates Gq BibTex
2009-06-02 R-HSA-400012 Acetylcholine binds Muscarinic Acetylcholine Receptor M3 BibTex
2008-12-02 R-HSA-9023159 Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) BibTex
2008-12-02 R-NUL-9023186 Carboxypeptidase E (rat Carboxypeptidase H) cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87)) BibTex
2008-12-02 R-HSA-9023173 Insulin secretory granule docks at the plasma membrane BibTex
2008-12-02 R-HSA-9023171 Insulin secretory granule translocates across the cortical actin network BibTex
2008-12-02 R-HSA-265160 Insulin secretory granule translocates to cell cortex BibTex
2008-12-02 R-HSA-9023178 PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) BibTex
2008-12-02 R-NUL-9023180 Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) BibTex
2008-12-02 R-HSA-9023163 Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54) BibTex
2008-12-02 R-NUL-9023166 Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54) BibTex
2008-12-02 R-HSA-9023196 PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) BibTex
2008-12-02 R-MMU-216806 Processing of Proinsulin to Insulin BibTex
2008-12-02 R-NUL-9023165 Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110) BibTex
2008-12-02 R-HSA-265153 Proinsulin:Zinc:Calcium complex translocates to immature secretory granule BibTex
2008-12-02 R-HSA-264976 Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium BibTex
2008-12-02 R-HSA-265010 Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi BibTex
2008-12-02 R-HSA-264997 Oxidation of cysteine to cystine in Proinsulin BibTex
2008-12-02 R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein BibTex
2008-12-02 R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum BibTex
2008-12-02 R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex BibTex
2008-12-02 R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) BibTex
2008-12-02 R-HSA-1799335 Synthesis of nascent polypeptide containing signal sequence BibTex
2008-12-02 R-HSA-1791121 Expression of XBP1(S) BibTex
2008-12-02 R-HSA-1791150 Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) BibTex
2008-12-02 R-HSA-1791082 Expression of Calreticulin BibTex
2008-12-02 R-HSA-1791163 Expression of HSP90B1 (Endoplasmin) BibTex
2008-12-02 R-HSA-1791076 Expression of ADD1 (Adducin alpha) BibTex
2008-12-02 R-HSA-1791143 Expression of YIF1A BibTex
2008-12-02 R-HSA-1791137 Expression of Talin-1 BibTex
2008-12-02 R-HSA-1791138 Expression of TPP1 BibTex
2008-12-02 R-HSA-1791139 Expression of SRPR (SRP Receptor subunit alpha) BibTex
2008-12-02 R-HSA-1791075 Expression of DNAJB11 BibTex
2008-12-02 R-HSA-1791084 Expression of SYVN1 (HRD1) BibTex
2008-12-02 R-HSA-1791144 Expression of EXTL3 BibTex
2008-12-02 R-HSA-1791083 Expression of Sec12 BibTex
2008-12-02 R-HSA-1791156 Expression of TATDN2 BibTex
2008-12-02 R-HSA-1791092 Expression of DCTN1 BibTex
2008-12-02 R-HSA-1791157 Expression of DNAJC3 (p58IPK) BibTex
2008-12-02 R-HSA-1791158 Expression of CXXC1 BibTex
2008-12-02 R-HSA-1791088 Expression of GFPT1 BibTex
2008-12-02 R-HSA-1791154 Expression of GOSR2 BibTex
2008-12-02 R-HSA-1791155 Expression of EDEM BibTex
2008-12-02 R-HSA-1791164 Expression of SSR1 (Trap alpha) BibTex
2008-12-02 R-HSA-1791102 Expression of C19orf10 BibTex
2008-12-02 R-HSA-1791167 Expression of SERP1 (RAMP4) BibTex
2008-12-02 R-HSA-1791096 Expression of PPP2R5B BibTex
2008-12-02 R-HSA-1791172 Expression of WIPI1 BibTex
2008-12-02 R-HSA-1791108 Expression of SULT1A3 BibTex
2008-12-02 R-HSA-1791169 Expression of WFS1 BibTex
2008-12-02 R-HSA-1791116 Expression of DDX11 BibTex
2008-12-02 R-HSA-1791054 Expression of GSK3A BibTex
2008-12-02 R-HSA-1791112 Expression of HDGF BibTex
2008-12-02 R-HSA-1791177 Expression of KLHDC3 BibTex
2008-12-02 R-HSA-1791114 Expression of FKBP14 BibTex
2008-12-02 R-HSA-1791060 Expression of SRPRB (SRP Receptor subunit beta) BibTex
2008-12-02 R-HSA-1791124 Expression of DNAJB9 BibTex
2008-12-02 R-HSA-1791184 Expression of ATP6VOD1 BibTex
2008-12-02 R-HSA-1791057 Expression of TSPYL2 BibTex
2008-12-02 R-HSA-1791186 Expression of ZBTB17 BibTex
2008-12-02 R-HSA-1791122 Expression of PDIA5 BibTex
2008-12-02 R-HSA-1791058 Expression of Cullin-7 BibTex
2008-12-02 R-HSA-1791123 Expression of KDELR3 BibTex
2008-12-02 R-HSA-1791133 Expression of Sec31A BibTex
2008-12-02 R-HSA-1791069 Expression of ACADVL BibTex
2008-12-02 R-HSA-381543 IGFBP4 binds IGF forming IGF:IGFBP4 BibTex
2008-12-02 R-HSA-381518 PAAP-A proteolyzes IGF:IGFBP4 BibTex
2008-12-02 R-HSA-381496 Formation of the IGF:IGFBP3:ALS complex BibTex
2008-12-02 R-HSA-381435 Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS BibTex
2008-12-02 R-HSA-381545 Formation of the IGF:IGFBP5:ALS complex BibTex
2008-12-02 R-HSA-381537 PAPP-A2 proteolyzes IGF:IGFBP5:ALS BibTex
2008-12-02 R-HSA-381461 Plasmin proteolyzes IGF:IGFBP-3:ALS BibTex
2008-12-02 R-HSA-381412 IGFBP2 binds IGF forming IGF:IGFBP2 BibTex
2008-12-02 R-HSA-381503 IGFBP6 binds IGF forming IGF:IGFBP6 BibTex
2008-12-02 R-HSA-381446 Thrombin proteolyzes IGF:IGFBP3:ALS BibTex
2008-12-02 R-HSA-381466 Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS BibTex
2008-12-02 R-HSA-381487 IGFBP1 binds IGF forming IGF:IGFBP1 BibTex
2008-12-02 R-HSA-381500 Cathepsin G proteolyzes IGF:IGFBP3:ALS BibTex
2008-12-02 R-HSA-381158 ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein BibTex
2008-12-02 R-HSA-381186 ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi BibTex
2008-12-02 R-HSA-381135 MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha) BibTex
2008-12-02 R-HSA-420818 MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha) BibTex
2008-12-02 R-HSA-381026 ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus BibTex
2008-12-02 R-HSA-381086 Dissociation of PERK:BiP Heterodimer BibTex
2008-12-02 R-HSA-381087 Dimerization of PERK BibTex
2008-12-02 R-HSA-381111 EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK BibTex
2008-12-02 R-HSA-381128 Translation of ATF4 BibTex
2008-12-02 R-HSA-517731 Expression of IL-8 BibTex
2008-12-02 R-HSA-1791118 Expression of ASNS (Asparagine Synthetase) BibTex
2008-12-02 R-HSA-1791180 Expression of IGFBP1 BibTex
2008-12-02 R-HSA-1791107 Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein BibTex
2008-12-02 R-HSA-1791056 Expression of CCL2 BibTex
2008-12-02 R-HSA-1791095 Expression of HERPUD BibTex
2008-12-02 R-HSA-1791173 Expression of ATF3 BibTex
2008-12-02 R-HSA-381217 IRE1:BiP dissociates in response to unfolded protein BibTex
2008-12-02 R-HSA-381109 IRE1 binds IRE1 forming dimer BibTex
2008-12-02 R-HSA-381091 IRE1 dimer autophosphorylates BibTex
2008-12-02 R-HSA-381116 Phosphorylated IRE1 dimer binds ADP BibTex
2008-12-02 R-HSA-425923 IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced BibTex
2008-12-02 R-HSA-381203 XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus BibTex
2008-12-02 R-HSA-1791131 Expression of PDIA6 (Protein disulfide-isomerase A6) BibTex
2008-12-02 R-HSA-1791130 Expression of CTDSP2 BibTex
2008-12-02 R-HSA-1791066 Expression of HYOU1 BibTex
2008-12-02 R-HSA-1791064 Expression of ARFGAP1 (GAP) BibTex
2008-12-02 R-HSA-1791128 Expression of LMNA BibTex
2008-12-02 R-HSA-1791071 Expression of PLA2G4B BibTex
2008-12-02 R-HSA-1791134 Expression of SHC1 BibTex
Cite Us!