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Ivo P Touw

 ORCID
https://orcid.org/0000-0002-4773-4074
Reviewed Reactions (37)
Date Identifier Reaction Reference
2020-12-12 R-HSA-9674816 p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS BibTex
2020-12-12 R-HSA-9674808 CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) BibTex
2020-12-12 R-MMU-9674973 Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11 BibTex
2020-12-12 R-HSA-9707977 CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane BibTex
2020-12-12 R-HSA-9705738 SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 BibTex
2020-12-12 R-HSA-9705729 SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 BibTex
2020-12-12 R-HSA-9705726 SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed BibTex
2020-12-12 R-HSA-9705467 SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 BibTex
2020-12-12 R-HSA-9705466 p-Y-STAT1,3,5 dimer enhances expression of SOCS1 BibTex
2020-12-12 R-MMU-9705455 p-Y-Stat1,3,5 dimer enhances expression of Socs1 BibTex
2020-12-12 R-HSA-9705458 p-Y-STAT1,3,5 dimer enhances expression of SOCS3 BibTex
2020-12-12 R-HSA-9705465 p-Y-STAT1,3,5 dimer binds SOCS3 gene BibTex
2020-12-12 R-MMU-9705459 p-Y-Stat1,3,5 dimer binds Socs3 gene BibTex
2020-12-12 R-MMU-9705464 p-Y-Stat1,3,5 dimer enhances expression of Socs3 BibTex
2020-12-12 R-MMU-9705471 Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 BibTex
2020-12-12 R-MMU-9707979 Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed BibTex
2020-12-12 R-MMU-9707972 Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7 BibTex
2020-12-12 R-HSA-9705461 p-Y-STAT1,3,5 dimer binds SOCS1 gene BibTex
2020-12-12 R-HSA-9674550 p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm BibTex
2020-12-12 R-HSA-9674542 p-Y-STAT1,3,5 dimerize BibTex
2020-12-12 R-HSA-9674563 CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 BibTex
2020-12-12 R-HSA-9674567 p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 BibTex
2020-12-12 R-HSA-9674562 CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 BibTex
2020-12-12 R-HSA-9676071 CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK BibTex
2020-12-12 R-HSA-9674558 p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 BibTex
2020-12-12 R-MMU-9674921 p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2 BibTex
2020-12-12 R-MMU-9676072 Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2 BibTex
2020-12-12 R-MMU-9674959 Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5 BibTex
2020-12-12 R-MMU-9674908 p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5 BibTex
2020-12-12 R-MMU-9674931 Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5 BibTex
2020-12-12 R-MMU-9676912 p-Y-Stat1,3,5 dimerize BibTex
2020-12-12 R-MMU-9676907 p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus BibTex
2020-12-12 R-MMU-9705472 p-Y-Stat1,3,5 dimer binds Socs1 gene BibTex
2020-12-12 R-HSA-9674546 CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 BibTex
2020-12-12 R-HSA-9677585 CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 BibTex
2020-12-12 R-HSA-9677579 CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN BibTex
2020-12-12 R-MMU-9674900 Csf3:Csf3r induces phosphorylation of Jak1 BibTex
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