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David P Hill

 ORCID
https://orcid.org/0000-0001-7476-6306
Affiliation
The Jackson Laboratory
Reviewed Reactions (159)
Date Identifier Reaction Reference
2024-03-01 R-HSA-9863531 GS-MCA spontaneously hydrolyzes BibTex
2024-02-23 R-HSA-6807826 LDHAL6B reduces PYR to LACT BibTex
2024-02-23 R-HSA-9861595 Cytosolic H2O2 decarboxylates PYR to acetate BibTex
2024-02-23 R-HSA-9861660 ME1 tetramer decarboxylates OA to PYR BibTex
2024-02-23 R-HSA-9861745 Mitochondrial H2O2 decarboxylates PYR to acetate BibTex
2024-02-23 R-HSA-9861640 CTLH E3 ligase ubiquitinates PKM-1 BibTex
2024-02-23 R-HSA-9861563 CTLH E3 ligase ubiquitinates LDHA BibTex
2024-02-23 R-HSA-9011543 DCA binds PDK2 BibTex
2024-02-23 R-HSA-9861626 SIRT4 cleaves lipoyl from DLAT BibTex
2024-02-23 R-HSA-9861616 DLD dimer dehydrogenates dihydrolipoyl BibTex
2024-02-23 R-HSA-9861667 DLAT trimer transfers acetyl to CoA BibTex
2024-02-23 R-HSA-9861734 PDH E1 decarboxylates PYR, transferring acetyl to DLAT BibTex
2024-02-23 R-HSA-203946 PDK isozymes phosphorylate PDHC subunit E1 BibTex
2024-02-23 R-HSA-204169 PDP1,2 dephosphorylate p-lipo-PDH BibTex
2024-02-23 R-HSA-9011595 GSTZ1 dimer dehalogenates DCA BibTex
2024-02-23 R-HSA-9861631 ME1 tetramerizes BibTex
2024-02-23 R-HSA-9861725 PGAM5 dodecamer dephosphorylates p-S336-ME1 BibTex
2024-02-23 R-HSA-9861642 NEK1 phosphorylates ME1 BibTex
2024-02-23 R-HSA-70501 PC carboxylates PYR to OA BibTex
2024-02-23 R-HSA-372342 MPC1:MPC2 imports PYR, H+ to mitochondrial matrix BibTex
2024-02-23 R-HSA-9012374 VDAC1 transports PYR from cytosol to mitochondrial intermembrane space BibTex
2024-02-23 R-HSA-70510 LDH tetramer oxidises LACT to PYR BibTex
2024-02-23 R-HSA-71849 LDH tetramer reduces PYR to LACT BibTex
2024-02-23 R-HSA-9012036 ME1 tetramer decarboxylates MAL to PYR BibTex
2024-02-23 R-HSA-70523 PXLP-K314-GPT transaminates L-Ala to form PYR BibTex
2024-02-23 R-HSA-71670 PKM dephosphorylates PEP to PYR BibTex
2024-02-23 R-HSA-9012268 ME2 tetramer decarboxylates MAL to PYR BibTex
2024-02-23 R-HSA-9012016 FAHD1 dimer hydrolyses OA to PYR BibTex
2024-02-23 R-HSA-9012349 ME3 tetramer decarboxylates MAL to PYR BibTex
2024-02-20 R-HSA-6793591 LIAS synthesizes lipoyl-GCSH BibTex
2024-02-20 R-HSA-6793590 LIPT2 transfers octanoyl group to GCSH BibTex
2024-02-20 R-HSA-9858752 LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT BibTex
2024-02-20 R-HSA-6792572 LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST BibTex
2024-02-16 R-HSA-9854315 CSKMT methylates Citrate Synthase BibTex
2024-02-16 R-HSA-9855212 SDHA binds to SDHB BibTex
2024-02-16 R-HSA-190141 ALAD binds to Pb2+ BibTex
2024-02-16 R-HSA-2995334 COX15 transforms heme O to heme A BibTex
2024-02-16 R-HSA-189421 CPO transforms COPRO3 to PPGEN9 BibTex
2024-02-16 R-HSA-189425 UROD decarboxylates URO3 to COPRO3 BibTex
2024-02-16 R-HSA-190182 UROD decarboxylates URO1 to COPRO1 BibTex
2024-02-16 R-HSA-189439 ALAD condenses 2 dALAs to form PBG BibTex
2024-02-16 R-HSA-5690886 ACO1, IREB2 bind IREs in TFRC, ALAD, FTL, FTH1 mRNAs BibTex
2024-02-16 R-HSA-917979 ABCG2 tetramer transports heme from cytosol to extracellular region BibTex
2024-02-16 R-HSA-5690873 ACO1 binds 4Fe-4S BibTex
2024-02-15 R-HSA-9856871 MDH1 reduces OA BibTex
2024-02-15 R-HSA-9854463 SIRT3 deacetylates AcK-IDH2 dimer BibTex
2024-02-15 R-HSA-9854405 Frataxin transfers Fe2+ to ACO2 BibTex
2024-02-15 R-HSA-9854415 ACAT1 tetramer acetylates IDH2 dimer BibTex
2024-02-15 R-HSA-9854368 ROS,RNS oxidize ACO2:4Fe-4S BibTex
2024-02-15 R-HSA-9853499 DLD dimer dehydrogenates dihydrolipoyl BibTex
2024-02-15 R-HSA-9853512 DLST transfers succinyl to CoA BibTex
2024-02-15 R-HSA-450971 NNT dimer transfers proton from NADPH to NAD+ BibTex
2024-02-15 R-HSA-450984 IDH2 dimer decarboxylates isocitrate BibTex
2024-02-15 R-HSA-70979 MDH2 dimer dehydrogenates MAL BibTex
2024-02-15 R-HSA-70975 CS acetylates OA to citrate BibTex
2024-02-15 R-HSA-70982 FH tetramer hydrates fumarate to L-malate BibTex
2024-02-15 R-HSA-70994 SDH complex dehydrogenates succinate BibTex
2024-02-15 R-HSA-70997 SUCLG1/A2 cleaves succinyl-CoA BibTex
2024-02-15 R-HSA-71401 OGDH dimer decarboxylates 2-OG BibTex
2024-02-15 R-HSA-70967 IDH3 complex decarboxylates isocitrate BibTex
2024-02-15 R-HSA-70971 ACO2 isomerizes citrate BibTex
2024-02-15 R-HSA-71775 SUCLG1/G2 cleaves succinyl-CoA BibTex
2024-02-15 R-HSA-9855252 SDHA:SDHB binds to SDHC:SDHD BibTex
2024-02-15 R-HSA-9854961 SDHAF4 binds to FAD-SDHA BibTex
2024-02-15 R-HSA-9854672 FAD attaches to SDHA BibTex
2024-02-15 R-HSA-9854984 Transfer of Fe-S clusters to SDHB BibTex
2024-02-13 R-HSA-163691 Phosphorylation of ChREBP at Serine 556 by AMPK BibTex
2024-02-12 R-HSA-163676 Phosphorylation of pChREBP (Thr 653) at Ser(196) by PKA BibTex
2024-02-12 R-HSA-163672 Phosphorylation of ChREBP at Thr(653) by PKA BibTex
2024-02-12 R-HSA-164151 LKB1 phosphorylates the alpha subunit of AMPK heterotrimer BibTex
2024-02-12 R-HSA-400097 G-beta:G-gamma inhibits Adenylate cyclase BibTex
2024-02-12 R-HSA-400037 Gi,Go Heterotrimeric G-protein complex dissociates BibTex
2024-02-12 R-HSA-400092 Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins BibTex
2024-02-12 R-HSA-400071 Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline BibTex
2024-02-12 R-HSA-381608 cAMP activates EPAC2 BibTex
2024-02-12 R-HSA-381668 cAMP activates EPAC1 BibTex
2024-02-12 R-HSA-381707 PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP BibTex
2024-02-12 R-HSA-381704 G(s):GTP activates Adenylyl cyclase BibTex
2024-02-12 R-HSA-9856605 Transcriptional activation of ACACB by ChREBP:MLX BibTex
2024-02-12 R-HSA-9856548 MLXIPL:MLX binds ACACB gene promoter BibTex
2024-02-12 R-HSA-163733 Transcriptional activation of FASN monomer gene by ChREBP:MLX BibTex
2024-02-12 R-HSA-9856546 MLXIPL:MLX binds FASN gene promoter BibTex
2024-02-12 R-HSA-163743 Transcriptional activation of ACACA by ChREBP:MLX BibTex
2024-02-12 R-HSA-9856550 MLXIPL:MLX binds ACACA gene promoter BibTex
2024-02-12 R-HSA-9856549 MLXIPL:MLX binds ACLY gene promoter BibTex
2024-02-12 R-HSA-163773 Phosphorylation of PF2K-Pase by PKA catalytic subunit BibTex
2024-02-12 R-HSA-381706 GLP1R:GLP1 activates G(s) BibTex
2024-02-12 R-HSA-400015 Diacylgycerol activates Protein kinase C, alpha type BibTex
2024-02-12 R-HSA-400012 Acetylcholine binds Muscarinic Acetylcholine Receptor M3 BibTex
2024-02-12 R-HSA-163748 Transcriptional activation of AGPAT1 by ChREBP:MLX BibTex
2024-02-12 R-HSA-9856604 MLXIPL:MLX binds AGPAT1 gene promoter BibTex
2024-02-12 R-HSA-163666 Formation of ChREBP:MLX heterodimer BibTex
2024-02-12 R-HSA-163669 Transcriptional activation of PKLR gene by ChREBP:MLX BibTex
2024-02-12 R-HSA-9856539 MLXIPL:MLX binds PKLR gene promoter BibTex
2024-02-12 R-HSA-1483087 PI is exchanged with PC by PITPNB BibTex
2024-02-12 R-HSA-1483229 PI:PITPNB is transported from the ER membrane to the Golgi membrane BibTex
2024-02-12 R-HSA-1483219 PC is exchanged with PI by PITPNB BibTex
2024-02-12 R-HSA-1483211 PC:PITPNB is transported from the Golgi membrane to the ER membrane BibTex
2023-11-06 R-HSA-9851407 FAM83B, (FAM83A, FAM83D) bind EGFR BibTex
2023-11-06 R-HSA-177934 EGFR autophosphorylation BibTex
2023-11-02 R-HSA-177922 EGFR dimerization BibTex
2023-07-26 R-HSA-196929 FLAD1 phosphorylates FMN BibTex
2023-07-26 R-HSA-196964 RFK:Mg2+ phosphorylates RIB BibTex
2023-07-26 R-HSA-196955 2xENPP1 hydrolyzes FAD to FMN BibTex
2023-07-26 R-HSA-9837419 PANK4 hydrolyzes PPANT to pantetheine BibTex
2023-07-26 R-HSA-9837354 NUDT8 hydrolyzes CoA-SH to PPANT BibTex
2023-07-26 R-MMU-9837342 Nudt8 hydrolyzes CoA-SH to PPANT BibTex
2023-07-26 R-HSA-9837337 DCAKD phosphorylates DP-CoA BibTex
2023-07-26 R-HSA-9837333 SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP BibTex
2023-07-26 R-HSA-196773 COASY phosphorylates DP-CoA BibTex
2023-07-26 R-HSA-196754 COASY transfers an adenylyl group from ATP to PPANT BibTex
2023-07-26 R-HSA-196840 3xPPCDC:3FMN decarboxylates PPC BibTex
2023-07-26 R-HSA-196753 2xPPCS ligates PPanK with Cys BibTex
2023-07-26 R-HSA-196857 PANK2 phosphorylates PanK BibTex
2023-07-26 R-HSA-199203 PANK1/3 phosphorylate PanK BibTex
2023-05-16 R-HSA-6799495 GLYCTK phosphorylates DGA to 3PDGA BibTex
2023-05-16 R-HSA-6813749 ALDH1A1 oxidises GA to DGA BibTex
2023-05-16 R-HSA-70342 ALDOB tetramer cleaves Fru-1-P to GA and DHAP BibTex
2023-05-16 R-HSA-70333 KHK dimer phosphorylates Fru to Fru 1-P BibTex
2023-05-16 R-HSA-5652195 SORD oxidizes D-sorbitol to Fru BibTex
2022-11-18 R-HSA-70420 HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P BibTex
2022-11-09 R-HSA-9817575 ERO1B oxidizes P4HB BibTex
2022-11-09 R-HSA-9820566 ZnT5 transports zinc into the golgi apparatus BibTex
2022-08-29 R-HSA-198458 Efflux of Glc from the endoplasmic reticulum BibTex
2022-08-29 R-HSA-3266566 G6PC2 hydrolyzes G6P to form Glc and Pi (islet) BibTex
2022-08-29 R-HSA-3257122 SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane BibTex
2022-08-29 R-HSA-71825 G6PC hydrolyzes G6P to Glc and Pi (liver) BibTex
2022-08-29 R-HSA-198513 SLC7A4 exchanges G6P for Pi across the ER membrane BibTex
2022-08-29 R-HSA-3262512 G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) BibTex
2022-08-29 R-HSA-70475 GPI dimer isomerizes Fru(6)P to G6P BibTex
2022-08-29 R-HSA-70479 FBP tetramers hydrolyze F1,6PP to Fru(6)P BibTex
2022-08-29 R-HSA-71495 Aldolase tetramers convert GA3P and DHAP to F1,6PP BibTex
2022-08-29 R-HSA-70481 TPI1 isomerizes GA3P to DHAP BibTex
2022-08-29 R-HSA-70482 GAPDH tetramers reduce 1,3BPG to GA3P BibTex
2022-08-29 R-HSA-70486 PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG BibTex
2022-08-29 R-HSA-71445 PGAM dimers (PGAM1,2) isomerise 2PG to 3PG BibTex
2022-08-29 R-HSA-70592 PXLP-K259-GOT1 transaminates 2-OG and L-Asp BibTex
2022-08-29 R-HSA-70613 GOT2 transaminates OA and L-Glu BibTex
2022-08-29 R-HSA-376851 SLC25A11 exchanges 2-OG and MAL BibTex
2022-08-29 R-HSA-70501 PC carboxylates PYR to OA BibTex
2022-08-29 R-HSA-372843 SLC25A10 mediates exchange of malate and phosphate BibTex
2022-08-29 R-HSA-70494 Enolase dimers (ENO1,2,3) convert PEP to 2PG BibTex
2022-08-29 R-HSA-372449 SLC25A1 may exchange mitochondrial PEP for cytosolic anion BibTex
2022-08-29 R-HSA-372819 PCK2 phosphorylates OA to yield PEP BibTex
2022-08-29 R-HSA-70241 PCK1 phosphorylates OA to yield PEP BibTex
2022-08-29 R-HSA-372448 SLC25A12,13 exchange L-Glu and L-Asp BibTex
2022-08-29 R-HSA-198440 SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane BibTex
2022-08-18 R-HSA-9792608 SLC35D2 exchanges UDP-D-glucose for UMP BibTex
2022-05-20 R-HSA-1678694 Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans BibTex
2022-05-20 R-HSA-2024084 HS-GAGs translocate to the lysosome for degradation BibTex
2022-05-20 R-HSA-2046239 Extracellular KSPG translocates to the lysosome for degradation BibTex
2022-05-19 R-HSA-741449 SLC35B2,3 transport cytosolic PAPS to Golgi lumen BibTex
2022-05-19 R-HSA-174389 PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS BibTex
2022-05-19 R-HSA-174392 PAPSS1,2 transfer SO4(2-) group to ATP to form APS BibTex
2022-05-19 R-HSA-427555 SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol BibTex
2022-02-14 R-HSA-9759549 Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin BibTex
2022-02-14 R-HSA-9759206 ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol BibTex
2022-02-14 R-HSA-9759202 LRP2-mediated TCN2:RCbl uptake and delivery to lysosome BibTex
2022-02-14 R-HSA-9759209 LRP2 binds extracellular TCN2:RCbl BibTex
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