Reactome | GSPT1 [cytosol]

GSPT1 [cytosol]

Stable Identifier

R-XTR-8865759

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

F6YEQ5

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        eRF3:GDP [cytosol] (Xenopus tropicalis)
        
        eRF3 [cytosol] (Xenopus tropicalis)
        
        GSPT1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6YEQ5

Reference Genes

ENSEMBL:ENSXETG00000005540

Participant Of

hasMember

eRF3 [cytosol]

Other forms of this molecule

GSPT2 [cytosol]

Inferred From

GSPT1 [cytosol] (Homo sapiens)