Reactome | fbxo21 [cytosol]

fbxo21 [cytosol]

Stable Identifier

R-XTR-8862592

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

FBXO21, B1H3J5

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)

Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Xenopus tropicalis)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        SCF E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        F-box protein [cytosol] (Xenopus tropicalis)
        
        fbxo21 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:B1H3J5

Gene Names

fbxo21

Reference Genes

BioGPS Gene:100145649 fbxo21

ENSEMBL:ENSXETG00000033734

KEGG Gene (Xenopus tropicalis):100145649 fbxo21

Monarch:100145649 fbxo21

NCBI Gene:100145649 fbxo21

Reference Transcript

RefSeq:NM_001127044.1 fbxo21

Other Identifiers

100145649

GO:0003677

GO:0005515

Participates

as a member of

F-box protein [cytosol] (Xenopus tropicalis)

Inferred From

FBXO21 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001120516.1

Xenbase

XB-GENE-973791

Ensembl

ENSXETT00000061399, ENSXETG00000033734, ENSXETP00000061276

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