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TYK2 [cytosol]
Stable Identifier
R-XTR-877348
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
A0A6I8QQ90
Locations in the PathwayBrowser
Expand all
Immune System (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
Interferon Signaling (Xenopus tropicalis)
Interferon alpha/beta signaling (Xenopus tropicalis)
Activation of JAK kinases (Xenopus tropicalis)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNAR1:TYK2 binds TYK2 inhibitors (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNAR1:TYK2:TYK2 inhibitors [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Recruitment of IFNAR1 (Xenopus tropicalis)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNAR1:TYK2:TYK2 inhibitors [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Regulation of IFNA/IFNB signaling (Xenopus tropicalis)
Dephosphorylation of TYK2 by PTP1B (Xenopus tropicalis)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Signaling by Interleukins (Xenopus tropicalis)
Interleukin-10 signaling (Xenopus tropicalis)
IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2 (Xenopus tropicalis)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Xenopus tropicalis)
IL10 dimer:2xIL10RA:JAK1:2xIL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Interleukin-12 family signaling (Xenopus tropicalis)
Interleukin-27 signaling (Xenopus tropicalis)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Xenopus tropicalis)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Interleukin-35 Signalling (Xenopus tropicalis)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Xenopus tropicalis)
IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Xenopus tropicalis)
IL-35:(IL6ST:JAK1:JAK2) dimer [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Interleukin-20 family signaling (Xenopus tropicalis)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)
IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL10RB binds TYK2 (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Xenopus tropicalis)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2 (Xenopus tropicalis)
IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Interleukin-6 family signaling (Xenopus tropicalis)
IL-6-type cytokine receptor ligand interactions (Xenopus tropicalis)
IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2) (Xenopus tropicalis)
IL6RA:IL6:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAKs bind LIFR (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAKs:LIFR [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAKs bind OSMR (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAKs:OSMR [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Interleukin-6 signaling (Xenopus tropicalis)
Assembly of hexameric IL-6 receptor (Xenopus tropicalis)
IL6 receptor hexamer:JAKs [plasma membrane] (Xenopus tropicalis)
IL6 receptor trimer:JAKs [plasma membrane] (Xenopus tropicalis)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL6 receptor trimer:JAKs [plasma membrane] (Xenopus tropicalis)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
JAK activation (Xenopus tropicalis)
IL6 receptor hexamer:JAKs [plasma membrane] (Xenopus tropicalis)
IL6 receptor trimer:JAKs [plasma membrane] (Xenopus tropicalis)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Xenopus tropicalis)
IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] (Xenopus tropicalis)
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
Other interleukin signaling (Xenopus tropicalis)
IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 (Xenopus tropicalis)
IFNL1:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
TYK2 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:A0A6I8QQ90
Reference Genes
BioGPS Gene:100489432
ENSEMBL:ENSXETG00000011623
KEGG Gene (Xenopus tropicalis):100489432
Monarch:100489432
NCBI Gene:100489432
Reference Transcript
RefSeq:XM_004918814.4
RefSeq:XM_002939674.5
RefSeq:XM_012953004.3
Other Identifiers
100489432
GO:0000166
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005524
GO:0005856
GO:0007165
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0035556
GO:0036211
GO:0043226
GO:0140096
Participates
as an input of
IL10RB binds TYK2 (Xenopus tropicalis)
as a component of
IL10RB:TYK2 [plasma membrane] (Xenopus tropicalis)
IFNAR1:TYK2 [plasma membrane] (Xenopus tropicalis)
as a candidate of
JAK1, JAK2, (TYK2) [cytosol] (Xenopus tropicalis)
Other forms of this molecule
phospho-p-TYK2 [cytosol]
phospho-p-Y-TYK2 [cytosol]
phospho-p-Y1054,Y1055-TYK2 [cytosol]
phospho-p-Y1054-TYK2 [cytosol]
Inferred From
TYK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_012808458.1
,
XP_004918871.1
,
XP_002939720.2
Ensembl
ENSXETG00000011623
,
ENSXETT00000073688
,
ENSXETP00000071450
Xenbase
XB-GENE-993652
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