Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PI3K [cytosol]
Stable Identifier
R-XTR-74693
Type
Complex
Species
Xenopus tropicalis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Hemostasis (Xenopus tropicalis)
Cell surface interactions at the vascular wall (Xenopus tropicalis)
Tie2 Signaling (Xenopus tropicalis)
Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p85 bound to Tie2 [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Innate Immune System (Xenopus tropicalis)
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
Role of LAT2/NTAL/LAB on calcium mobilization (Xenopus tropicalis)
PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
RAS:GTP binds PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p21 RAS:GTP:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
Active ALK recruits PI3K (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by Insulin receptor (Xenopus tropicalis)
Insulin receptor signalling cascade (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes [cytosol] (Xenopus tropicalis)
Activated FGFR bound to PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by LTK (Xenopus tropicalis)
Active LTK receptor binds PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
PI3K/AKT activation (Xenopus tropicalis)
Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
PI3-kinase binds to the active receptor (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by SCF-KIT (Xenopus tropicalis)
Synthesis of PIP3 from PIP2 by PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Xenopus tropicalis)
IGF1R signaling cascade (Xenopus tropicalis)
IRS-related events triggered by IGF1R (Xenopus tropicalis)
IRS-mediated signalling (Xenopus tropicalis)
PI3K Cascade (Xenopus tropicalis)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
PI3K-containing complexes [cytosol] (Xenopus tropicalis)
Activated FGFR bound to PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
p-AXL binds PI3K (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K [cytosol] (Xenopus tropicalis)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-catalytic subunit [cytosol]
(Xenopus tropicalis)
PI3K-regulatory subunit [cytosol]
(Xenopus tropicalis)
Participates
as an input of
Active ALK recruits PI3K (Xenopus tropicalis)
Active LTK receptor binds PI3K (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
Interaction of Tie2 and p85 of PI3K (Xenopus tropicalis)
RAS:GTP binds PI3K (Xenopus tropicalis)
PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)
p-AXL binds PI3K (Xenopus tropicalis)
PI3-kinase binds to the active receptor (Xenopus tropicalis)
Active IRS recruits PI3K to the plasma membrane and activates it (Xenopus tropicalis)
as a component of
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Xenopus tropicalis)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Xenopus tropicalis)
Activated FGFR bound to PI3K [cytosol] (Xenopus tropicalis)
p85 bound to Tie2 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:PI3K [plasma membrane] (Xenopus tropicalis)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Xenopus tropicalis)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Xenopus tropicalis)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Xenopus tropicalis)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Xenopus tropicalis)
Inferred From
PI3K [cytosol]
(Homo sapiens)
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
