Reactome | grb2 [cytosol]

grb2 [cytosol]

Stable Identifier

R-XTR-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

GRB2-1, Q66II3

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - NCAM signaling for neurite out-growth (Xenopus tropicalis)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Xenopus tropicalis)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Xenopus tropicalis)
        
        pFAK:Grb2:Sos [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
    - RET signaling (Xenopus tropicalis)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - p-5Y-RET complexes bind GRB2 (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Costimulation by the CD28 family (Xenopus tropicalis)
    - CD28 co-stimulation (Xenopus tropicalis)
      - CD28 dependent Vav1 pathway (Xenopus tropicalis)
        
        Activation of Cdc42 by pVav1 (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        Activation of Rac1 by pVav1 (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        Activation of Vav1 (Xenopus tropicalis)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        Grb2 binds CD28 (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        Translocation of Vav1 to CD28 (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - FLT3 Signaling (Xenopus tropicalis)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Xenopus tropicalis)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Xenopus tropicalis)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Xenopus tropicalis)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
    - SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Xenopus tropicalis)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Xenopus tropicalis)
      - Regulation of signaling by CBL (Xenopus tropicalis)
        
        CBL ubiquitinates PI3K (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - DAP12 interactions (Xenopus tropicalis)
    - DAP12 signaling (Xenopus tropicalis)
      - Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Release of p-PLCG1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
      - Autophosphorylation of BTK/ITK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Activation of RAC1 by VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Autophosphorylation of PAK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Phosphorylation and activation of VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Xenopus tropicalis)
      - PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        grb2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q66II3

Gene Names

grb2

Reference Genes

BioGPS Gene:493492 grb2

ENSEMBL:ENSXETG00000012520

KEGG Gene (Xenopus tropicalis):493492 grb2

Monarch:493492 grb2

NCBI Gene:493492 grb2

Reference Transcript

Other Identifiers

493492

GO:0005154

GO:0005515

GO:0005634

GO:0005737

GO:0005768

GO:0005794

GO:0008286

GO:0022414

GO:0023052

GO:0031410

GO:0043226

GO:0043560

GO:0051321

Participates

as a component of

as a member of

RHOU effectors [cytosol] (Xenopus tropicalis)

as an input of

as an output of

PPTN11 dephosphorylates SPRY2 (Xenopus tropicalis)

Inferred From

GRB2 [cytosol] (Homo sapiens)

GRB2-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012827142.1, NP_001008130.1, XP_012827141.1, XP_012827139.1, XP_012827140.1

Ensembl

ENSXETP00000118282, ENSXETT00000107991, ENSXETG00000012520

Xenbase

XB-GENE-6070000

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