Reactome | GRB2-1 [cytosol]

GRB2-1 [cytosol]

Stable Identifier

R-XTR-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

Q66II3

Locations in the PathwayBrowser

Expand all

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Costimulation by the CD28 family (Xenopus tropicalis)
    - CD28 co-stimulation (Xenopus tropicalis)
      - CD28 dependent Vav1 pathway (Xenopus tropicalis)
        
        Activation of Cdc42 by pVav1 (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activation of Rac1 by pVav1 (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activation of Vav1 (Xenopus tropicalis)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Grb2 binds CD28 (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Translocation of Vav1 to CD28 (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        CD28:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
  - Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Xenopus tropicalis)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Xenopus tropicalis)
        
        BLNK:GRB2:SOS1:CIN85 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - FLT3 Signaling (Xenopus tropicalis)
    - PI3K Cascade (Xenopus tropicalis)
      - PI3K-containing complexes phosphorylate PIP2 to PIP3 (Xenopus tropicalis)
        
        PI3K-containing complexes [plasma membrane] (Xenopus tropicalis)
        
        Activated FGFR bound to PI3K [plasma membrane] (Xenopus tropicalis)
        
        GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - RAF/MAP kinase cascade (Xenopus tropicalis)
      - RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
        
        RAS GEFs [plasma membrane] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1:p-Y-SHC [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2:SOS1:p-KIT complex [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Xenopus tropicalis)
        
        pFAK:Grb2:Sos [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        SOS-1 bound to Tie2:Grb2 [plasma membrane] (Xenopus tropicalis)
        
        Grb2 bound to Tie2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        Active FLT3: GRB2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-2 family signaling (Xenopus tropicalis)
      - Interleukin-15 signaling (Xenopus tropicalis)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Xenopus tropicalis)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Xenopus tropicalis)
      - Regulation of signaling by CBL (Xenopus tropicalis)
        
        CBL ubiquitinates PI3K (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Xenopus tropicalis)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - DAP12 interactions (Xenopus tropicalis)
    - DAP12 signaling (Xenopus tropicalis)
      - Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Release of p-PLCG1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
      - Autophosphorylation of BTK/ITK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of TEC kinases by p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Activation of RAC1 by VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Autophosphorylation of PAK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Interaction of GRB2:SOS complex with p-SHC1 (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation and activation of VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of SLP-76 by p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - SOS mediated nucleotide exchange of RAS (SHC) (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Xenopus tropicalis)
      - PI3K associates with phosphorylated GAB2 (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Xenopus tropicalis)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Xenopus tropicalis)
        
        p-SHC1:GRB2:SOS [cytosol] (Xenopus tropicalis)
        
        GRB2-1:SOS1 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Xenopus tropicalis)
    - Regulation of actin dynamics for phagocytic cup formation (Xenopus tropicalis)
      - Activation of WASP/N-WASP by WIP family and SH3 domain proteins (Xenopus tropicalis)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Attachment of preexisting mother filament and initiation of branching (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Xenopus tropicalis)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Xenopus tropicalis)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Detachment of WASP/WAVE (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Xenopus tropicalis)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        Mother filament:branching complex [cytosol] (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP:ARP2/3 complex:G-actin [cytosol] (Xenopus tropicalis)
        
        Activated WAVE2 and WASP/N-WASP [plasma membrane] (Xenopus tropicalis)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of WASP/N-WASP (Xenopus tropicalis)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [cytosol] (Xenopus tropicalis)
        
        SH3 domain proteins [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - Clathrin-mediated endocytosis (Xenopus tropicalis)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        p-Y371-CBL:GRB2 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Xenopus tropicalis)
        
        p-Y371-CBL:GRB2 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)
    - BAR domain proteins recruit dynamin (Xenopus tropicalis)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Xenopus tropicalis)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        CLASP proteins:cargo [plasma membrane] (Xenopus tropicalis)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        ubiquitinated cargo [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        p-Y371-CBL:GRB2 [cytosol] (Xenopus tropicalis)
        
        GRB2-1 [cytosol] (Xenopus tropicalis)