Reactome | rps18 [cytosol]

rps18 [cytosol]

Stable Identifier

R-XTR-72341

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RPS18, A9JSA5

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        40S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        rps18 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A9JSA5

Gene Names

rps18

Reference Genes

BioGPS Gene:549112 rps18

ENSEMBL:ENSXETG00000020394

KEGG Gene (Xenopus tropicalis):549112 rps18

Monarch:549112 rps18

NCBI Gene:549112 rps18

Reference Transcript

RefSeq:NM_001016358.2 rps18

Participates

as a component of

40S ribosomal complex [cytosol] (Xenopus tropicalis)

Other forms of this molecule

rps18 [nucleoplasm]

Inferred From

RPS18 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001016358.1

Xenbase

XB-GENE-488842

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