Reactome | fen1 [nucleoplasm]

fen1 [nucleoplasm]

Stable Identifier

R-XTR-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

FEN1, F7B7H6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:F7B7H6

Gene Names

fen1

Reference Genes

BioGPS Gene:549759 fen1

ENSEMBL:ENSXETG00000006703

KEGG:xtr:549759 fen1

Monarch:549759 fen1

NCBI Gene:549759 fen1

UCSC:F7B7H6 fen1

Reference Transcript

RefSeq:NM_001017005.2 fen1

Other Identifiers

549759

GO:0000287

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0004527

GO:0005634

GO:0005654

GO:0005730

GO:0005739

GO:0006260

GO:0006281

GO:0006284

GO:0006974

GO:0008409

GO:0016787

GO:0016788

GO:0017108

GO:0043137

GO:0043226

GO:0046872

GO:0140097

Participates

as an input of

PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Xenopus tropicalis)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Xenopus tropicalis)

as a component of

APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Xenopus tropicalis)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Xenopus tropicalis)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Xenopus tropicalis)

Inferred From

FEN1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001017005.1

ENSEMBL

ENSXETP00000014663, ENSXETT00000014663, ENSXETT00000105747, ENSXETP00000104143

Xenbase

XB-GENE-955518