Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
derl2 [endoplasmic reticulum membrane]
Stable Identifier
R-XTR-5362350
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
endoplasmic reticulum membrane
Synonyms
DERL2, Q28F56
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Signaling by Hedgehog (Xenopus tropicalis)
Hedgehog ligand biogenesis (Xenopus tropicalis)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Xenopus tropicalis)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
Transport of small molecules (Xenopus tropicalis)
ABC-family proteins mediated transport (Xenopus tropicalis)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Xenopus tropicalis)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
ERAD complex [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERL oligomer [endoplasmic reticulum membrane] (Xenopus tropicalis)
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
derl2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q28F56
Gene Names
derl2
Reference Genes
BioGPS Gene:548851 derl2
ENSEMBL:ENSXETG00000009183
KEGG Gene (Xenopus tropicalis):548851 derl2
Monarch:548851 derl2
NCBI Gene:548851 derl2
Reference Transcript
RefSeq:NM_001016097.3 derl2
Other Identifiers
548851
GO:0005783
GO:0005789
GO:0006950
GO:0010033
GO:0010498
GO:0016020
GO:0030163
GO:0043226
Participates
as a component of
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
as a candidate of
DERLs [endoplasmic reticulum membrane] (Xenopus tropicalis)
Inferred From
DERL2 [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001016097.1
Xenbase
XB-GENE-5936600
Ensembl
ENSXETP00000020156
,
ENSXETG00000009183
,
ENSXETT00000020156
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text