Reactome | phospho-p-Y650,Y656-EPHA5 [plasma membrane]

phospho-p-Y650,Y656-EPHA5 [plasma membrane]

Stable Identifier

R-XTR-3928343

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

plasma membrane

Synonyms

A0A6I8QSX7

Locations in the PathwayBrowser

Expand all

Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - EPH receptors autophosphorylate (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
      - EPH-ephrin mediated repulsion of cells (Xenopus tropicalis)
        
        EPHA binds TIAM1 (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        SFKs phosphorylate VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        p-EPHs bind VAV2,3 (Xenopus tropicalis)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Xenopus tropicalis)
        
        p-EPH:ephrin oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)
      - EPHA-mediated growth cone collapse (Xenopus tropicalis)
        
        NGEF exchanges GTP for GDP on RHOA (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Xenopus tropicalis)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs:EFNAs [plasma membrane] (Xenopus tropicalis)
        
        p-EPHAs [plasma membrane] (Xenopus tropicalis)
        
        phospho-p-Y650,Y656-EPHA5 [plasma membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8QSX7

Reference Genes

BioGPS Gene:100488002

ENSEMBL:ENSXETG00000034200

Monarch:100488002

NCBI Gene:100488002

Reference Transcript

RefSeq:XM_012955378.3

Other Identifiers

100488002

GO:0000166

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0007169

GO:0007399

GO:0016020

GO:0016740

GO:0023052

GO:0036211

GO:0048013

GO:0048856

GO:0060089

GO:0140096

Participates

as a member of

p-EPHAs [plasma membrane] (Xenopus tropicalis)

Other forms of this molecule

EPHA5 [plasma membrane]

Inferred From

p-Y650,Y656-EPHA5 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 650 (in Homo sapiens)

Coordinate

650

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 656 (in Homo sapiens)

Coordinate

656

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_012810832.1

Ensembl

ENSXETT00000078480, ENSXETG00000034200, ENSXETP00000071493

Xenbase

XB-GENE-988387

Cite Us!