Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
smad2 [cytosol]
Stable Identifier
R-XTR-3006353
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
SMAD2, F7AQA6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Xenopus tropicalis)
RNA Polymerase II Transcription (Xenopus tropicalis)
Generic Transcription Pathway (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Deubiquitination (Xenopus tropicalis)
Ub-specific processing proteases (Xenopus tropicalis)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Xenopus tropicalis)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Xenopus tropicalis)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by TGFB family members (Xenopus tropicalis)
Signaling by Activin (Xenopus tropicalis)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
Signaling by TGF-beta Receptor Complex (Xenopus tropicalis)
TGF-beta receptor signaling activates SMADs (Xenopus tropicalis)
Downregulation of TGF-beta receptor signaling (Xenopus tropicalis)
Degradation of ubiquitinated SMAD2 (Xenopus tropicalis)
Ub-SMAD2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)
SMAD2/3:PMEPA1 [plasma membrane] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
SMURF2 binds SMAD2 (Xenopus tropicalis)
SMAD2:SMURF2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
SMURF2 ubiquitinates SMAD2 (Xenopus tropicalis)
SMAD2:SMURF2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
Ub-SMAD2 [cytosol] (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Xenopus tropicalis)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Xenopus tropicalis)
Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
smad2 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F7AQA6
Gene Names
smad2
Reference Genes
ENSEMBL:ENSXETG00000020292
UCSC:F7AQA6 smad2
Reference Transcript
RefSeq:XM_012960846.2 smad2
RefSeq:XM_018092817.1 smad2
RefSeq:XM_012960839.2 smad2
RefSeq:XM_018092812.1 smad2
RefSeq:XM_031899043.1 smad2
RefSeq:XM_031899046.1 smad2
Other Identifiers
496586
GO:0000978
GO:0000981
GO:0003677
GO:0005634
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0007179
GO:0009653
GO:0030154
GO:0032924
GO:0043226
GO:0045944
GO:0046872
GO:0060395
GO:0070411
GO:0071144
GO:0140110
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Xenopus tropicalis)
as an input of
PMEPA1 sequesters unphosphorylated SMAD2/3 (Xenopus tropicalis)
SMURF2 binds SMAD2 (Xenopus tropicalis)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Xenopus tropicalis)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Xenopus tropicalis)
as a component of
SMAD2/3:PMEPA1 [plasma membrane] (Xenopus tropicalis)
Ub-SMAD2 [cytosol] (Xenopus tropicalis)
SMAD2:SMURF2 [cytosol] (Xenopus tropicalis)
as an output of
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)
Other forms of this molecule
smad2 [cytosol]
phospho-smad2 [cytosol]
smad2 [nucleoplasm]
phospho-smad2 [cytosol]
Inferred From
SMAD2,3 [cytosol]
(Homo sapiens)
SMAD2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_017948301.1
,
XP_031754906.1
,
XP_031754903.1
,
XP_012816300.1
,
XP_017948306.1
,
XP_012816293.1
ENSEMBL
ENSXETP00000043789
,
ENSXETT00000043789
,
ENSXETG00000020292
Xenbase
XB-GENE-482930
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text