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mdk [extracellular region]
Stable Identifier
R-XTR-2160953
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
extracellular region
Synonyms
MDK, Q6P8F3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Signaling by NOTCH (Xenopus tropicalis)
Signaling by NOTCH2 (Xenopus tropicalis)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Xenopus tropicalis)
NOTCH2 binds MDK (Xenopus tropicalis)
MDK [extracellular region] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
MDK:NOTCH2 [plasma membrane] (Xenopus tropicalis)
MDK [extracellular region] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
ALK autophosphorylation (Xenopus tropicalis)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK binds JAK3 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK binds PLCG1 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK dimer binds IRS1 (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates IRS1 (Xenopus tropicalis)
Active ALK:IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:pY-IRS1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates JAK3 (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:p-Y980 JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates PLCG1 (Xenopus tropicalis)
Active ALK:PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:p-4Y PLCG1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK phosphorylates SHC1 (Xenopus tropicalis)
Active ALK:SHC1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:p-3Y SHC1 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK recruits PI3K (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Liganded-ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
ligand-bound ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
MDK and PTN in ALK signaling (Xenopus tropicalis)
ALK binds ligand midkine (MDK) (Xenopus tropicalis)
MDK:ALK [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
PI3K synthesizes PIP3 downstream of ALK (Xenopus tropicalis)
Active ALK:PI3K [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
PTPN6 dephosphorylates JAK3 (Xenopus tropicalis)
Active ALK:JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
Active ALK:p-Y980 JAK3 [plasma membrane] (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
STAT3 is phosphorylated downstream of active ALK (Xenopus tropicalis)
Active ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
mdk [extracellular region] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q6P8F3
Gene Names
mdk
Reference Genes
BioGPS Gene:394671 mdk
ENSEMBL:ENSXETG00000001967
KEGG:xtr:394671 mdk
Monarch:394671 mdk
NCBI Gene:394671 mdk
UCSC:Q6P8F3 mdk
Reference Transcript
RefSeq:NM_203743.1 mdk
Other Identifiers
394671
GO:0004252
GO:0005576
GO:0006508
GO:0007165
GO:0007399
GO:0007528
GO:0008083
GO:0008201
GO:0008233
GO:0008236
GO:0009617
GO:0016787
GO:0030154
GO:0034330
GO:0042742
GO:0043395
GO:0048018
GO:0048856
GO:0051781
GO:0098542
GO:0098772
Participates
as a component of
MDK [extracellular region] (Xenopus tropicalis)
MDK:ALK [plasma membrane] (Xenopus tropicalis)
MDK:ALK dimer [plasma membrane] (Xenopus tropicalis)
MDK:p-7Y ALK dimer [plasma membrane] (Xenopus tropicalis)
as an input of
ALK binds ligand midkine (MDK) (Xenopus tropicalis)
Inferred From
PTN,MDK [extracellular region]
(Homo sapiens)
MDK [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_989074.1
ENSEMBL
ENSXETT00000107034
,
ENSXETT00000004204
,
ENSXETG00000001967
,
ENSXETP00000004204
,
ENSXETP00000112640
Xenbase
XB-GENE-488502
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