Reactome | socs1 [cytosol]

socs1 [cytosol]

Stable Identifier

R-XTR-204910

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

SOCS1, Q5M8D9

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
    - Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
      - Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
      - Polyubiquitination of substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
      - Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
      - Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        E3:Ub:substrate [cytosol] (Xenopus tropicalis)
        
        E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
        
        RBX1-CUL5-EloB/C-SOCS [cytosol] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Interferon Signaling (Xenopus tropicalis)
    - Interferon alpha/beta signaling (Xenopus tropicalis)
      - Activation of JAK kinases (Xenopus tropicalis)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Xenopus tropicalis)
        
        p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
  - Signaling by CSF3 (G-CSF) (Xenopus tropicalis)
    - Inactivation of CSF3 (G-CSF) signaling (Xenopus tropicalis)
      - SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Xenopus tropicalis)
        
        SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)
        
        socs1 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q5M8D9

Gene Names

socs1

Reference Genes

BioGPS Gene:496789 socs1

ENSEMBL:ENSXETG00000024895

KEGG Gene (Xenopus tropicalis):496789 socs1

Monarch:496789 socs1

NCBI Gene:496789 socs1

Reference Transcript

Other Identifiers

496789

GO:0002376

GO:0009968

GO:0016567

GO:0023052

GO:0030154

GO:0032868

GO:0035162

GO:0035556

GO:0036211

GO:0042509

GO:0046426

GO:0048856

GO:0048870

GO:0051896

GO:0060042

GO:0060336

GO:0098542

GO:2000406

Participates

as a member of

SOCS-1 and SOCS-3 [cytosol] (Xenopus tropicalis)

Inferred From

SOCS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001011327.1, XP_017952584.1, XP_017952585.1, XP_017952583.1

Ensembl

ENSXETG00000024895, ENSXETT00000117905, ENSXETT00000118904, ENSXETP00000119291, ENSXETP00000008137, ENSXETP00000111855, ENSXETT00000008137

Xenbase

XB-GENE-491220

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