Reactome | rps6ka1 [nucleoplasm]

rps6ka1 [nucleoplasm]

Stable Identifier

R-XTR-199860

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

RPS6KA1, A0A6I8SXX2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular Senescence (Xenopus tropicalis)
    - Senescence-Associated Secretory Phenotype (SASP) (Xenopus tropicalis)
      - ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Cytokine Signaling in Immune system (Xenopus tropicalis)
  - Signaling by Interleukins (Xenopus tropicalis)
    - Interleukin-17 signaling (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - Toll-like Receptor Cascades (Xenopus tropicalis)
    - Toll Like Receptor 10 (TLR10) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 2 (TLR2) Cascade (Xenopus tropicalis)
      - Toll Like Receptor TLR1:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
      - Toll Like Receptor TLR6:TLR2 Cascade (Xenopus tropicalis)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 3 (TLR3) Cascade (Xenopus tropicalis)
      - MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 4 (TLR4) Cascade (Xenopus tropicalis)
      - MyD88-independent TLR4 cascade (Xenopus tropicalis)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 5 (TLR5) Cascade (Xenopus tropicalis)
      - MyD88 cascade initiated on plasma membrane (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
    - Toll Like Receptor 9 (TLR9) Cascade (Xenopus tropicalis)
      - MyD88 dependent cascade initiated on endosome (Xenopus tropicalis)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
        
        MAP kinase activation (Xenopus tropicalis)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G alpha (q) signalling events (Xenopus tropicalis)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by NTRKs (Xenopus tropicalis)
    - Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
      - Nuclear Events (kinase and transcription factor activation) (Xenopus tropicalis)
        
        ERK/MAPK targets (Xenopus tropicalis)
        
        ERK1/2/5 activate RSK1/2/3 (Xenopus tropicalis)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)
        
        rps6ka1 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8SXX2

Gene Names

rps6ka1

Reference Genes

BioGPS Gene:100144704 rps6ka1

ENSEMBL:ENSXETG00000012289

Monarch:100144704 rps6ka1

NCBI Gene:100144704 rps6ka1

UCSC:A0A6I8SXX2 rps6ka1

Reference Transcript

RefSeq:XM_012956411.3 rps6ka1

Other Identifiers

100144704

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004676

GO:0004677

GO:0004679

GO:0004694

GO:0004711

GO:0005524

GO:0006325

GO:0006338

GO:0006468

GO:0016740

GO:0035175

GO:0035402

GO:0035403

GO:0035556

GO:0035979

GO:0044022

GO:0044023

GO:0044024

GO:0044025

GO:0072354

GO:0072371

GO:0072518

GO:0140096

GO:0140823

GO:0140855

GO:0140857

GO:1990244

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Xenopus tropicalis)

Other forms of this molecule

phospho-rps6ka1 [cytosol]

phospho-rps6ka1 [nucleoplasm]

Inferred From

RPS6KA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_012811865.1

ENSEMBL

ENSXETT00000080974, ENSXETG00000012289, ENSXETP00000100111

Xenbase

XB-GENE-479496

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