Reactome | RAD9B [nucleoplasm]

RAD9B

Stable Identifier

R-XTR-176325

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

F6ZZT3

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle Checkpoints (Xenopus tropicalis)
  - G2/M Checkpoints (Xenopus tropicalis)
    - Activation of ATR in response to replication stress (Xenopus tropicalis)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
    - G2/M DNA damage checkpoint (Xenopus tropicalis)
      - ATR phosphorylates TP53 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)

DNA Repair (Xenopus tropicalis)

- DNA Double-Strand Break Repair (Xenopus tropicalis)
  - Homology Directed Repair (Xenopus tropicalis)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
      - HDR through Homologous Recombination (HRR) (Xenopus tropicalis)
        
        Homologous DNA Pairing and Strand Exchange (Xenopus tropicalis)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Xenopus tropicalis)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
      - HDR through Single Strand Annealing (SSA) (Xenopus tropicalis)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        ERCC1:XPF cleaves flaps generated by SSA (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
      - Processing of DNA double-strand break ends (Xenopus tropicalis)
        
        ATR activation at DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        ATR phosphorylates RPA2 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        Activation of CHEK1 at resected DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        CHEK1 is recruited to resected DNA DSBs (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - Regulation of TP53 Activity (Xenopus tropicalis)
        
        Regulation of TP53 Activity through Phosphorylation (Xenopus tropicalis)
        
        ATR phosphorylates TP53 (Xenopus tropicalis)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9 [nucleoplasm] (Xenopus tropicalis)
        
        RAD9B [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6ZZT3

Reference Genes

ENSEMBL:ENSXETG00000020936

Other Identifiers

AAMC01072935

AAMC01072936

AAMC01072937

AAMC01072938

ENSXETG00000020936

ENSXETP00000045245

ENSXETT00000045245

GO:0000075

GO:0000076

GO:0000077

GO:0000228

GO:0000278

GO:0003674

GO:0004518

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005694

GO:0006259

GO:0006281

GO:0006950

GO:0007049

GO:0008150

GO:0008408

GO:0030896

GO:0031573

GO:0034641

GO:0043226

GO:0043234

GO:0071479

GO:0090305

IPR007268

PF04139

rad9b-201

StrEns.5853.1.S1_at

UPI000206639D

XB-GENE-990519

Participant Of

hasMember

RAD9 [nucleoplasm]

Inferred From

RAD9B [nucleoplasm] (Homo sapiens)