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EGF-like ligands [extracellular region]
Stable Identifier
R-XTR-1233230
Type
Set [DefinedSet]
Species
Xenopus tropicalis
Compartment
extracellular region
Synonyms
EGF-like growth factors
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Intracellular signaling by second messengers (Xenopus tropicalis)
PIP3 activates AKT signaling (Xenopus tropicalis)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
Activator:PI3K [plasma membrane] (Xenopus tropicalis)
PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
RAS GEFs [plasma membrane] (Xenopus tropicalis)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ERBB4 (Xenopus tropicalis)
ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)
ERBB4:EGFR heterodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Homodimerization of ERBB4 (Xenopus tropicalis)
ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
ERBB4jmAcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
ERBB4jmBcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
PI3K events in ERBB4 signaling (Xenopus tropicalis)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
SHC1 events in ERBB4 signaling (Xenopus tropicalis)
Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)
SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)
ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
ERBB4jmAcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
ERBB4jmBcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
EGF-like ligands [extracellular region] (Xenopus tropicalis)
Participants
members
btc [extracellular region]
(Xenopus tropicalis)
hbegf [extracellular region]
(Xenopus tropicalis)
Participates
as a component of
NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
as an input of
ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)
Inferred From
NRGs/EGF-like ligands [extracellular region]
(Homo sapiens)
EGF-like ligands [extracellular region]
(Homo sapiens)
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