Reactome | cish [cytosol]

cish [cytosol]

Stable Identifier

R-XTR-1169213

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

CISH, F7BIB9

Locations in the PathwayBrowser

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Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Neddylation (Xenopus tropicalis)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Xenopus tropicalis)
        
        CRL E3 ubiquitin ligases [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Xenopus tropicalis)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Xenopus tropicalis)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Xenopus tropicalis)
        
        CUL5-box protein [cytosol] (Xenopus tropicalis)
        
        cish [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7BIB9

Gene Names

cish

Reference Genes

BioGPS Gene:100135018 cish

ENSEMBL:ENSXETG00000000078

Monarch:100135018 cish

NCBI Gene:100135018 cish

Reference Transcript

RefSeq:XM_012960556.3 cish

Other Identifiers

100135018

GO:0009968

GO:0016567

GO:0023052

GO:0035556

GO:0036211

Participates

as a member of

CUL5-box protein [cytosol] (Xenopus tropicalis)

Inferred From

CISH [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012816010.1

Xenbase

XB-GENE-490099

Ensembl

ENSXETP00000053945, ENSXETT00000053945, ENSXETG00000000078

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