Cdk1 phosphorylates condensin I

Stable Identifier
R-XLA-2520871
Type
Reaction [transition]
Species
Xenopus laevis
Compartment
General
SVG |   | PPTX  | SBGN
Cdk1 phosphorylates condensin I

Cdk1 (Cdc2) in complex with Ccnb (cyclin B) phosphorylates condensin I subunits Ncapd2, Ncapg and Ncaph in mitotic Xenopus egg extracts. While phosphorylation sites in Ncapg and Ncaph have not been identified, Ncapd2 is phosphorylated on threonine residues T1314, T1348 and T1353 (Kimura et al. 1998) which are conserved in human and mouse orthologs. Phosphorylation by Cdk1 enables condensin I to introduce positive supercoils into DNA and promotes chromatin condensation (Kimura et al. 1998).

Literature References
PubMed ID Title Journal Year
9774278 Phosphorylation and activation of 13S condensin by Cdc2 in vitro

Kimura, K, Hirano, M, Kobayashi, R, Hirano, T

Science 1998
Participants
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of p-T161-Cdk1:Ccnb [cytosol]

Orthologous Events
Authored
Reviewed
Created
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