Reactome | KMT2B dimer [nucleoplasm]

KMT2B dimer [nucleoplasm]

Stable Identifier

R-SSC-9818619

Type

Complex

Species

Sus scrofa

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Sus scrofa)

- Epigenetic regulation of gene expression (Sus scrofa)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Sus scrofa)
    - Formation of WDR5-containing histone-modifying complexes (Sus scrofa)
      - AKAP8L binds MLL2 complex (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        MLL2 complex:AKAP8L [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
      - Formation of the MLL2 complex (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
      - MEN1 binds MLL2 complex (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        MLL2 complex:MEN1 [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
      - PSIP1 binds MEN1 associated with MLL2 complex (Sus scrofa)
        
        MLL2 complex:MEN1 [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        MLL2 complex:MEN1:PSIP1 [nucleoplasm] (Sus scrofa)
        
        MLL2 complex:MEN1 [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Sus scrofa)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Sus scrofa)
        
        Core MLL complex [nucleoplasm] (Sus scrofa)
        
        MLL2 complex [nucleoplasm] (Sus scrofa)
        
        KMT2B dimer [nucleoplasm] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as an input of

Formation of the MLL2 complex (Sus scrofa)

as a component of

MLL2 complex [nucleoplasm] (Sus scrofa)

Inferred From

KMT2B dimer [nucleoplasm] (Homo sapiens)

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