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KEAP1 [cytosol]
Stable Identifier
R-SSC-976038
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
KEAP1, Q684M4
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to chemical stress (Sus scrofa)
KEAP1-NFE2L2 pathway (Sus scrofa)
CUL3:RBX1 ubiquitinates KEAP1 (Sus scrofa)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Sus scrofa)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Sus scrofa)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Class I MHC mediated antigen processing & presentation (Sus scrofa)
Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Polyubiquitination of substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Release of E3 from polyubiquitinated substrate (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
E3:Ub:substrate [cytosol] (Sus scrofa)
E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Deubiquitination (Sus scrofa)
Ub-specific processing proteases (Sus scrofa)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Sus scrofa)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Sus scrofa)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Neddylation (Sus scrofa)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
NEDD8-CUL3:RBX1:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
RBX1:CUL3:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
NEDD8-CUL3:RBX1:BTB [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Sus scrofa)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
KEAP1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:Q684M4
Gene Names
KEAP1
Reference Genes
BioGPS Gene:100136900 KEAP1
ENSEMBL:ENSSSCG00000023667.4 KEAP1
ENSEMBL:ENSSSCG00005034266.1 KEAP1
ENSEMBL:ENSSSCG00015075784.1 KEAP1
ENSEMBL:ENSSSCG00025076625.1 KEAP1
ENSEMBL:ENSSSCG00030027089.1 KEAP1
ENSEMBL:ENSSSCG00035023559.1 KEAP1
ENSEMBL:ENSSSCG00040004054.1 KEAP1
ENSEMBL:ENSSSCG00045007314.1 KEAP1
ENSEMBL:ENSSSCG00050019378.1 KEAP1
ENSEMBL:ENSSSCG00055028108.1 KEAP1
ENSEMBL:ENSSSCG00060036281.1
ENSEMBL:ENSSSCG00065078612.1 KEAP1
KEGG Gene (Sus scrofa):100136900 KEAP1
Monarch:100136900 KEAP1
NCBI Gene:100136900 KEAP1
Reference Transcript
RefSeq:XM_013987396.1 KEAP1
RefSeq:NM_001114671.1 KEAP1
RefSeq:XM_005654811.2 KEAP1
RefSeq:XM_013987435.1 KEAP1
RefSeq:XM_003480796.3 KEAP1
RefSeq:XM_005654858.2 KEAP1
Other Identifiers
100136900
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006351
GO:0006355
GO:0006511
GO:0006914
GO:0008152
GO:0010506
GO:0016234
GO:0016567
GO:0030154
GO:0030163
GO:0030496
GO:0031463
GO:0032991
GO:0034451
GO:0034599
GO:0036211
GO:0042802
GO:0043226
GO:0045604
GO:0048856
GO:0060090
GO:0061629
GO:0070887
GO:0071353
GO:0097718
GO:1990756
Ssc.11795.1.S1_at
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Sus scrofa)
BTB proteins [cytosol] (Sus scrofa)
as a component of
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Sus scrofa)
Other forms of this molecule
KEAP1 [cytosol]
KEAP1 [cytosol]
Inferred From
KEAP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005654915.1
,
XP_013842850.1
,
XP_013842889.1
,
XP_005654868.1
,
NP_001108143.1
,
XP_003480844.1
OpenTargets
ENSG00000079999
Ensembl
ENSSSCT00000064933
,
ENSSSCG00000023667
,
ENSSSCP00000056325
VGNC
89419
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