Reactome | phospho-p-T195-ORC6 [nucleoplasm]

phospho-p-T195-ORC6 [nucleoplasm]

Stable Identifier

R-SSC-9734715

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

I3LLV3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Activation of claspin (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - Loading of claspin onto DNA during replication origin firing (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - DNA polymerase epsilon binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Assembly of the ORC complex at the origin of replication (Sus scrofa)
      - Formation of ORC(1-6) complex (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
      - ORC6 translocates to the nucleus (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
    - CDC6 association with the ORC:origin complex (Sus scrofa)
      - CDC6 association with ORC(1-6) at replication origins (Sus scrofa)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
        
        ORC(1-6):origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        CDC6:ORC:origin complex [nucleoplasm] (Sus scrofa)
        
        ORC:origin of replication [nucleoplasm] (Sus scrofa)
        
        phospho-p-T195-ORC6 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3LLV3

Reference Genes

ENSEMBL:ENSSSCG00000024443.4

ENSEMBL:ENSSSCG00005038058.1

Reference Transcript

RefSeq:XM_013992381.1

Other Identifiers

100624779

GO:0000228

GO:0000808

GO:0001650

GO:0003677

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005730

GO:0006260

GO:0006270

GO:0043226

Ssc.16990.1.S1_at

Participates

as an input of

Formation of ORC(1-6) complex (Sus scrofa)

as an output of

ORC6 translocates to the nucleus (Sus scrofa)

as a component of

Other forms of this molecule

ORC6 [nucleoplasm]

ORC6 [cytosol]

phospho-p-T195-ORC6 [cytosol]

Inferred From

p-T195-ORC6 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 195 (in Homo sapiens)

Coordinate

195

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_013847835.1

Ensembl

ENSSSCT00000030366, ENSSSCG00000024443, ENSSSCP00000025073

VGNC

91063

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