Reactome | K63polyUb-K30,K401-TBK1 homodimer [cytosol]

K63polyUb-K30,K401-TBK1 homodimer [cytosol]

Stable Identifier

R-SSC-9730427

Type

Complex

Species

Sus scrofa

Compartment

cytosol

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Sus scrofa)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Sus scrofa)
        
        TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4 (Sus scrofa)
        
        K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)
        
        K63polyUb-K30,K401-TBK1 homodimer [cytosol] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 K63polyUb-K30,K401-TBK1 [cytosol] (Sus scrofa)

Participates

as a component of

K63polyUb-TBK1:K63polyUb-TANK:K63pUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Sus scrofa)

Inferred From

K63polyUb-K30,K401-TBK1 homodimer [cytosol] (Homo sapiens)

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