Reactome | CaMKII dodecamer [cytosol]

CaMKII dodecamer [cytosol]

Stable Identifier

R-SSC-9611355

Type

Complex

Species

Sus scrofa

Compartment

cytosol

Locations in the PathwayBrowser

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Neuronal System (Sus scrofa)

- Transmission across Chemical Synapses (Sus scrofa)
  - Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
    - Activation of NMDA receptors and postsynaptic events (Sus scrofa)
      - Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)
        
        Ca2+ influx into the post-synaptic cell (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        CaMKII dodecamer [cytosol] (Sus scrofa)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        CaMKII dodecamer [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
        
        RAS GEFs [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Sus scrofa)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Sus scrofa)
        
        CaMKII dodecamer [cytosol] (Sus scrofa)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 12 CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Sus scrofa)

Participates

as a component of

Inferred From

CaMKII dodecamer [cytosol] (Homo sapiens)

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