Reactome | EIF4A3 [cytosol]

EIF4A3 [cytosol]

Stable Identifier

R-SSC-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

A6M931

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Deadenylation-dependent mRNA decay (Sus scrofa)
  - Deadenylation of mRNA (Sus scrofa)
    - CCR4-NOT complex deadenylates mRNA (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
    - PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - Translatable mRNA Complex [cytosol] (Sus scrofa)
        
        eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
    - PARN deadenylates mRNA (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - eIF4A [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Transport of Mature Transcript to Cytoplasm (Sus scrofa)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Sus scrofa)
      - Transport of the export-competent mRNP complex through the NPC (Sus scrofa)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
      - mRNP complex dissociates from cytosolic face of NPC (Sus scrofa)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Sus scrofa)
        
        EJC [cytosol] (Sus scrofa)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)
        
        EIF4A3 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A6M931

Reference Genes

BioGPS Gene:100101926

ENSEMBL:ENSSSCG00000017155

ENSEMBL:ENSSSCG00000017155.5

ENSEMBL:ENSSSCG00025064355.1

ENSEMBL:ENSSSCG00035079500.1

ENSEMBL:ENSSSCG00040056176.1

ENSEMBL:ENSSSCG00045017772.1

ENSEMBL:ENSSSCG00050037808.1

ENSEMBL:ENSSSCG00055019309.1

ENSEMBL:ENSSSCG00060066806.1

ENSEMBL:ENSSSCG00065071434.1

ENSEMBL:ENSSSCG00070017212.1

KEGG Gene (Sus scrofa):100101926

Monarch:100101926

NCBI Gene:100101926

Reference Transcript

RefSeq:NM_001100193.1

Other Identifiers

100101926

GO:0000184

GO:0000398

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0008143

GO:0016071

GO:0017148

GO:0035145

GO:0043226

GO:0045727

GO:0048701

GO:0048856

GO:0071006

GO:0071013

GO:0140098

GO:0140657

GO:2000622

Ssc.869.1.S1_at

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Sus scrofa)

as a member of

eIF4A [cytosol] (Sus scrofa)

Other forms of this molecule

EIF4A3 [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001093663.1

IntEnz

3.6.4.13

Ensembl

ENSSSCG00000017155, ENSSSCT00000018679, ENSSSCP00000018178

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