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CALM1 [cytosol]
Stable Identifier
R-SSC-9016707
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
cytosol
Synonyms
A0A287AUC1
Locations in the PathwayBrowser
Expand all
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Response to elevated platelet cytosolic Ca2+ (Sus scrofa)
Platelet degranulation (Sus scrofa)
Release of platelet cytosolic components (Sus scrofa)
Platelet releasate cytosolic proteins [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Platelet homeostasis (Sus scrofa)
Platelet calcium homeostasis (Sus scrofa)
Reduction of cytosolic Ca++ levels (Sus scrofa)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Immune System (Sus scrofa)
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
CLEC7A (Dectin-1) induces NFAT activation (Sus scrofa)
Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)
NFAT:CaN:CaM [cytosol] (Sus scrofa)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Sus scrofa)
PPP3CA,B:Calmodulin [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)
NFAT:CaN:CaM [cytosol] (Sus scrofa)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Sus scrofa)
PPP3CA,B:Calmodulin [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Metabolism (Sus scrofa)
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP3 and IP4 in the cytosol (Sus scrofa)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Sus scrofa)
ITPKA/B/C [cytosol] (Sus scrofa)
ITPKA:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
ITPKB:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
ITPKC:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Metabolism of carbohydrates (Sus scrofa)
Glycogen metabolism (Sus scrofa)
Glycogen breakdown (glycogenolysis) (Sus scrofa)
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Sus scrofa)
phosphorylase kinase complex (PHKL) [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Sus scrofa)
phosphorylase kinase complex (PHKM) [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Metabolism of nitric oxide (Sus scrofa)
eNOS activation and regulation (Sus scrofa)
eNOS activation (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Uncoupled eNOS favours the formation of superoxide (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Sus scrofa)
BH2 binding can lead to eNOS uncoupling (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Metabolism of proteins (Sus scrofa)
Post-translational protein modification (Sus scrofa)
Protein methylation (Sus scrofa)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Ion homeostasis (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Phase 0 - rapid depolarisation (Sus scrofa)
SCNAs:SNCBs transport Na+ from extracellular region to cytosol (Sus scrofa)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Smooth Muscle Contraction (Sus scrofa)
MYLK (MLCK) Active Calmodulin Binding (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
MYLK:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Phosphorylation of Smooth Muscle Myosin Light Chains (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
MYLK:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter receptors and postsynaptic signal transmission (Sus scrofa)
Activation of NMDA receptors and postsynaptic events (Sus scrofa)
Post NMDA receptor activation events (Sus scrofa)
Activation of RAC1 downstream of NMDARs (Sus scrofa)
CAMK1 binds calmodulin (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
CAMK1:CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
CaMKK autophosphorylates in the cytosol (Sus scrofa)
CaMKK:CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-CaMKK:CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Long-term potentiation (Sus scrofa)
Calmodulin binds neurogranin (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
CALM1:NRGN [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Sus scrofa)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Activation of kainate receptors upon glutamate binding (Sus scrofa)
Ionotropic activity of kainate receptors (Sus scrofa)
Activation of Ca-permeable Kainate Receptor (Sus scrofa)
Activation of Ca-permeable Kainate receptors (Sus scrofa)
Kainate receptor-glutamate complex [plasma membrane] (Sus scrofa)
Kainate Receptors [plasma membrane] (Sus scrofa)
GRIK 2 homomer [plasma membrane] (Sus scrofa)
GRIK2 interacting proteins [plasma membrane] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
kainate receptor binds glutamate (Sus scrofa)
Kainate Receptors [plasma membrane] (Sus scrofa)
GRIK 2 homomer [plasma membrane] (Sus scrofa)
GRIK2 interacting proteins [plasma membrane] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Kainate receptor-glutamate complex [plasma membrane] (Sus scrofa)
Kainate Receptors [plasma membrane] (Sus scrofa)
GRIK 2 homomer [plasma membrane] (Sus scrofa)
GRIK2 interacting proteins [plasma membrane] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Signal Transduction (Sus scrofa)
Intracellular signaling by second messengers (Sus scrofa)
DAG and IP3 signaling (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
Cam-PDE 1 activation (Sus scrofa)
Calmodulin activates Cam-PDE 1 (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Inhibition of ADRBK2 by calmodulin (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
GRK2:calmodulin [plasma membrane] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
PKA-mediated phosphorylation of CREB (Sus scrofa)
PKA activation (Sus scrofa)
Adenylate cyclase produces cAMP (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
MAPK family signaling cascades (Sus scrofa)
MAPK1/MAPK3 signaling (Sus scrofa)
RAF/MAP kinase cascade (Sus scrofa)
RAF activation (Sus scrofa)
Phosphorylation of RAF (Sus scrofa)
RAF activating kinases [plasma membrane] (Sus scrofa)
p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
RAS GEFs promote RAS nucleotide exchange (Sus scrofa)
RAS GEFs [plasma membrane] (Sus scrofa)
Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
G-protein mediated events (Sus scrofa)
PLC beta mediated events (Sus scrofa)
Ca-dependent events (Sus scrofa)
CaM pathway (Sus scrofa)
Calmodulin induced events (Sus scrofa)
Cam-PDE 1 activation (Sus scrofa)
Calmodulin activates Cam-PDE 1 (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Inhibition of ADRBK2 by calmodulin (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
GRK2:calmodulin [plasma membrane] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
PKA-mediated phosphorylation of CREB (Sus scrofa)
PKA activation (Sus scrofa)
Adenylate cyclase produces cAMP (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Visual phototransduction (Sus scrofa)
The phototransduction cascade (Sus scrofa)
Inactivation, recovery and regulation of the phototransduction cascade (Sus scrofa)
CALM1:Ca2+ binds CNG channel (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
CALM1:Ca2+:CNG channel [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1 (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by VEGF (Sus scrofa)
VEGFA-VEGFR2 Pathway (Sus scrofa)
VEGFR2 mediated vascular permeability (Sus scrofa)
AKT1 phosphorylates eNOS (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
eNOS synthesizes NO (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Sus scrofa)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
eNOS:Caveolin-1 complex binds to CaM (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Signaling by Rho GTPases (Sus scrofa)
RHO GTPase Effectors (Sus scrofa)
RHO GTPases activate PAKs (Sus scrofa)
MYLK (MLCK) Active Calmodulin Binding (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
MYLK:Ca2+:CALM1 [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
Ca2+ pathway (Sus scrofa)
Active calmodulin binds CAMK2 (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
CAMK2:CaM [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Autophosphorylation and activation of CAMK2 (Sus scrofa)
CAMK2:CaM [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-T286 CAMK2:CaM [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Dissociation of CaM and CAMK2 autophosphorylation (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
p-T286 CAMK2:CaM [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Translocation of NFATC1:CaN:CaM to nucleus (Sus scrofa)
NFATC1:CaN:CaM [cytosol] (Sus scrofa)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Sus scrofa)
PPP3CA,B:Calmodulin [cytosol] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Ion transport by P-type ATPases (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
CAMK2 heteromer:CALM:4xCa2+ [plasma membrane] (Sus scrofa)
CALM1:4xCa2+ [cytosol] (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
Stimuli-sensing channels (Sus scrofa)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Sodium/Calcium exchangers (Sus scrofa)
SLC8A1,2,3 exchange 3Na+ for Ca2+ (Sus scrofa)
CALM1 [cytosol] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287AUC1
Reference Genes
ENSEMBL:ENSSSCG00000029019
Other Identifiers
AEMK02000074
ENSSSCG00000029019
ENSSSCP00000047519
ENSSSCT00000029535
GO:0003674
GO:0005509
GO:0005575
GO:0005622
GO:0005623
GO:0007165
GO:0008150
GO:0019722
GO:0043167
IPR002048
IPR011992
IPR018247
PF13499
PF13833
SM00054
UPI000BAD7DD7
Participant Of
hasMember
Platelet releasate cytosolic proteins [cytosol]
input
Calmodulin binds neurogranin
Inhibition of ADRBK2 by calmodulin
KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1
hasComponent
CALM1:4xCa2+ [cytosol]
CALM1:NRGN [cytosol]
GRIK2 interacting proteins [plasma membrane]
GRK2:calmodulin [plasma membrane]
ITPKA:Ca2+:CALM1 [cytosol]
ITPKB:Ca2+:CALM1 [cytosol]
ITPKC:Ca2+:CALM1 [cytosol]
phosphorylase kinase complex (PHKL) [cytosol]
phosphorylase kinase complex (PHKM) [cytosol]
This entity regulates
Negatively
SLC8A1,2,3 exchange 3Na+ for Ca2+
Other forms of this molecule
CALM1 [extracellular region]
Me3K115-CALM1 [cytosol]
CALM1 [plasma membrane]
CALM1 [nucleoplasm]
Inferred From
CALM1 [cytosol] (Homo sapiens)
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