Reactome | VRK3 [nucleoplasm]

VRK3 [nucleoplasm]

Stable Identifier

R-SSC-8942507

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

VRK3, A0A287AHL0

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-17 signaling (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        MAP kinase activation (Sus scrofa)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - Nuclear Events (kinase and transcription factor activation) (Sus scrofa)
        
        ERK/MAPK targets (Sus scrofa)
        
        ERKs are inactivated (Sus scrofa)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Sus scrofa)
        
        VRK3:DUSP3 [nucleoplasm] (Sus scrofa)
        
        VRK3 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AHL0

Gene Names

VRK3

Reference Genes

ENSEMBL:ENSSSCG00000003204.5

Other Identifiers

100523004

GO:0003824

GO:0004672

GO:0005524

GO:0005634

GO:0005654

GO:0006468

GO:0007519

GO:0016740

GO:0019903

GO:0023052

GO:0036211

GO:0043226

GO:0043231

GO:0048856

GO:0070373

GO:0140096

Ssc.4069.1.S1_at

Ssc.4069.2.S1_at

Ssc.4069.3.S1_at

Participates

as a component of

VRK3:DUSP3 [nucleoplasm] (Sus scrofa)

Inferred From

VRK3 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000105053

Ensembl

ENSSSCG00000003204, ENSSSCP00000043376, ENSSSCT00000055317

VGNC

98409

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