Reactome | GNAS [plasma membrane]

GNAS [plasma membrane]

Stable Identifier

R-SSC-8873940

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

GNAS1, A5GFT9

Locations in the PathwayBrowser

Expand all

Hemostasis (Sus scrofa)

- Platelet homeostasis (Sus scrofa)
  - Prostacyclin signalling through prostacyclin receptor (Sus scrofa)
    - Gs activation by prostacyclin receptor (Sus scrofa)
      - Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GTP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
      - Prostacyclin:prostacyclin receptor:Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)

Metabolism (Sus scrofa)

- Integration of energy metabolism (Sus scrofa)
  - Regulation of insulin secretion (Sus scrofa)
    - Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Sus scrofa)
      - GLP1R binds GLP1 (Sus scrofa)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
      - GLP1R binds GLP1R agonists (Sus scrofa)
        
        GLP1R:GLP1R agonists [plasma membrane] (Sus scrofa)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR downstream signalling (Sus scrofa)
    - G alpha (s) signalling events (Sus scrofa)
      - GPER1 signaling (Sus scrofa)
        
        ESTG stimulates GTP exchange on GPER:heterotrimeric G-protein s (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs (active):ESTG [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GTP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GPER:Heterotrimeric G-protein Gs binds ESTG (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs:ESTG [plasma membrane] (Sus scrofa)
        
        GPER1:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Sus scrofa)
        
        Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs:GDP [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (active) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GTP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class B/2 (Secretin family receptors) (Sus scrofa)
      - Glucagon-type ligand receptors (Sus scrofa)
        
        GLP1R binds GLP1 (Sus scrofa)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)

Transport of small molecules (Sus scrofa)

- Aquaporin-mediated transport (Sus scrofa)
  - Vasopressin regulates renal water homeostasis via Aquaporins (Sus scrofa)
    - AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Sus scrofa)
      - AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Sus scrofa)
        
        G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Sus scrofa)
        
        G alpha (s):GDP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
      - AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Sus scrofa)
        
        G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Sus scrofa)
        
        G alpha (s):GTP [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)
        
        GNAS [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A5GFT9

Gene Names

GNAS

Reference Genes

ENSEMBL:ENSSSCG00000007520.6

Other Identifiers

100049657

GO:0000166

GO:0001501

GO:0001894

GO:0001958

GO:0002376

GO:0003824

GO:0003924

GO:0003925

GO:0005159

GO:0005525

GO:0005834

GO:0005886

GO:0006091

GO:0006112

GO:0006306

GO:0006325

GO:0007165

GO:0007186

GO:0007189

GO:0007191

GO:0007606

GO:0009410

GO:0009791

GO:0010854

GO:0010856

GO:0016020

GO:0016787

GO:0019001

GO:0023052

GO:0030154

GO:0030425

GO:0031683

GO:0031698

GO:0031748

GO:0031852

GO:0032024

GO:0035116

GO:0035255

GO:0035264

GO:0040032

GO:0043588

GO:0045669

GO:0045672

GO:0046872

GO:0048701

GO:0048856

GO:0050877

GO:0050886

GO:0050896

GO:0051216

GO:0051430

GO:0071377

GO:0071514

GO:0098772

GO:0110165

GO:0120162

GO:2000828

Ssc.6675.1.S1_a_at

Participates

as a candidate of

GNAS [plasma membrane] (Sus scrofa)

Inferred From

GNAS1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000087460

Ensembl

ENSSSCG00000007520, ENSSSCP00000029311, ENSSSCT00000033038

Cite Us!