Reactome | KIAA0319 [plasma membrane]

KIAA0319 [plasma membrane]

Stable Identifier

R-SSC-8864136

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

plasma membrane

Synonyms

KIAA0319, A0A5G2RC25

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - BAR domain proteins recruit dynamin (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - AP-2 directly binds some endocytic cargo (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - SNX9 recruits components of the actin polymerizing machinery (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        AP-2:cargo [plasma membrane] (Sus scrofa)
        
        AP-2 cargo [plasma membrane] (Sus scrofa)
        
        AP-2 YXXPhi cargo [plasma membrane] (Sus scrofa)
        
        KIAA0319 dimer [plasma membrane] (Sus scrofa)
        
        KIAA0319 [plasma membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2RC25

Gene Names

KIAA0319

Reference Genes

ENSEMBL:ENSSSCG00000001091.5

Other Identifiers

100738226

GO:0001764

GO:0005515

GO:0005768

GO:0005769

GO:0005886

GO:0010996

GO:0023052

GO:0030154

GO:0030517

GO:0031410

GO:0033555

GO:0043226

GO:0043231

GO:0048692

GO:0048856

GO:0048870

GO:0060391

GO:2000171

Ssc.27762.1.S1_at

Participates

as a component of

KIAA0319 dimer [plasma membrane] (Sus scrofa)

Other forms of this molecule

KIAA0319 [clathrin-coated endocytic vesicle membrane]

Inferred From

KIAA0319 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000137261

Ensembl

ENSSSCP00000071752, ENSSSCT00000087274, ENSSSCG00000001091

VGNC

89429

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