Reactome | phospho-GAB2 [cytosol]

phospho-GAB2 [cytosol]

Stable Identifier

R-SSC-8855574

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-5Y-GAB2, A0A287B630

Locations in the PathwayBrowser

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Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - RET signaling (Sus scrofa)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB2 [cytosol] (Sus scrofa)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB2 [cytosol] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB2 [cytosol] (Sus scrofa)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB2 [cytosol] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Sus scrofa)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)
        
        phospho-GAB2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287B630

Gene Names

GAB2

Reference Genes

ENSEMBL:ENSSSCG00000014891.5

Other Identifiers

100513609

GO:0005068

GO:0005737

GO:0005886

GO:0007165

GO:0007169

GO:0008284

GO:0023052

GO:0030154

GO:0030316

GO:0048856

GO:0060090

Ssc.26599.1.A1_at

Participates

as a member of

p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Sus scrofa)

Other forms of this molecule

phospho-GAB2 [cytosol]

GAB2 [cytosol]

phospho-GAB2 [cytosol]

Inferred From

p-5Y-GAB2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 452 (in Homo sapiens)

Coordinate

452

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 476 (in Homo sapiens)

Coordinate

476

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 584 (in Homo sapiens)

Coordinate

584

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 614 (in Homo sapiens)

Coordinate

614

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 643 (in Homo sapiens)

Coordinate

643

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000033327

Ensembl

ENSSSCG00000014891, ENSSSCT00000063586, ENSSSCP00000051969