Reactome | PIK3CB [cytosol]

Developmental Biology (Sus scrofa)

- Nervous system development (Sus scrofa)
  - Axon guidance (Sus scrofa)
    - RET signaling (Sus scrofa)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Sus scrofa)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)

Hemostasis (Sus scrofa)

- Cell surface interactions at the vascular wall (Sus scrofa)
  - Tie2 Signaling (Sus scrofa)
    - Interaction of Tie2 and p85 of PI3K (Sus scrofa)
      - PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - p85 bound to Tie2 [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- Platelet activation, signaling and aggregation (Sus scrofa)
  - GPVI-mediated activation cascade (Sus scrofa)
    - GPVI stimulates PI3K beta, gamma (Sus scrofa)
      - PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - PI3K alpha, beta, gamma convert PIP2 to PIP3 (Sus scrofa)
      - PI3K alpha, beta, gamma [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Downstream TCR signaling (Sus scrofa)
      - PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - Recruitment of PI3K to plasma membrane (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-2 family signaling (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Sus scrofa)
      - 14-3-3 zeta binding allows recruitment of PI3K (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - Interleukin receptor SHC signaling (Sus scrofa)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Sus scrofa)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - Regulation of signaling by CBL (Sus scrofa)
        
        CBL ubiquitinates PI3K (Sus scrofa)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        K63polyUb-PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Sus scrofa)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p85-containing Class 1A PI3Ks [cytosol] (Sus scrofa)
        
        PI3K beta [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Sus scrofa)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Sus scrofa)
      - PI3K associates with phosphorylated GAB2 (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Role of phospholipids in phagocytosis (Sus scrofa)
      - PI3K binds to p-6Y-SYK (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K:p-6Y-SYK [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)

Metabolism (Sus scrofa)

- Metabolism of lipids (Sus scrofa)
  - Phospholipid metabolism (Sus scrofa)
    - PI Metabolism (Sus scrofa)
      - Synthesis of PIPs at the plasma membrane (Sus scrofa)
        
        PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Sus scrofa)
        
        PIK3C(1) [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R2 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R3 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Sus scrofa)
        
        PIK3(2) [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R2 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R3 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - Negative regulation of the PI3K/AKT network (Sus scrofa)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Sus scrofa)
        
        PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        Activator:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - Activator:PI3K [plasma membrane] (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K bound to TRAT [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - RAS:GTP binds PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p21 RAS:GTP:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- Signaling by Erythropoietin (Sus scrofa)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Sus scrofa)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
      - PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K bound to EPOR [plasma membrane] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K alpha, gamma [cytosol] (Sus scrofa)
        
        PIK3CB:PIK3R1 [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
- Signaling by Receptor Tyrosine Kinases (Sus scrofa)
  - Signaling by ALK (Sus scrofa)
    - Active ALK recruits PI3K (Sus scrofa)
      - Active ALK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
    - PI3K synthesizes PIP3 downstream of ALK (Sus scrofa)
      - Active ALK:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by Insulin receptor (Sus scrofa)
    - Insulin receptor signalling cascade (Sus scrofa)
      - IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by NTRKs (Sus scrofa)
    - Signaling by NTRK1 (TRKA) (Sus scrofa)
      - PI3K/AKT activation (Sus scrofa)
        
        Active IRS recruits PI3K to the plasma membrane and activates it (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
        
        Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by PDGF (Sus scrofa)
    - Downstream signal transduction (Sus scrofa)
      - PI3-kinase binds to the active receptor (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - PI3K catalyses the phosphorylation of PIP2 to PIP3 (Sus scrofa)
        
        PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by SCF-KIT (Sus scrofa)
    - Synthesis of PIP3 from PIP2 by PI3K (Sus scrofa)
      - PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Sus scrofa)
    - IGF1R signaling cascade (Sus scrofa)
      - IRS-related events triggered by IGF1R (Sus scrofa)
        
        IRS-mediated signalling (Sus scrofa)
        
        PI3K Cascade (Sus scrofa)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Sus scrofa)
        
        PI3K-containing complexes [cytosol] (Sus scrofa)
        
        Activated FGFR bound to PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
  - Signaling by VEGF (Sus scrofa)
    - VEGFA-VEGFR2 Pathway (Sus scrofa)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
      - p-AXL binds PI3K (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Sus scrofa)
        
        PI3K [cytosol] (Sus scrofa)
        
        PI3K-catalytic subunit [cytosol] (Sus scrofa)
        
        PIK3CB [cytosol] (Sus scrofa)