Reactome | EIF4E [cytosol]

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Interferon Signaling (Sus scrofa)
    - Antiviral mechanism by IFN-stimulated genes (Sus scrofa)
      - ISG15 antiviral mechanism (Sus scrofa)
        
        Competitive inhibition of translation initiation by ISGylated 4EHP (Sus scrofa)
        
        EIF4F [cytosol] (Sus scrofa)
        
        EIF4E1/EIF4E3 [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        eIF4F:mRNA [cytosol] (Sus scrofa)
        
        EIF4F [cytosol] (Sus scrofa)
        
        EIF4E1/EIF4E3 [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Deadenylation-dependent mRNA decay (Sus scrofa)
  - Deadenylation of mRNA (Sus scrofa)
    - CCR4-NOT complex deadenylates mRNA (Sus scrofa)
      - EIF4E [cytosol] (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
    - PAN2-PAN3 complex partially deadenylates mRNA (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
      - Translatable mRNA Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
    - PARN deadenylates mRNA (Sus scrofa)
      - EIF4E [cytosol] (Sus scrofa)
      - Partially Deadenylated mRNA Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Transport of Mature Transcript to Cytoplasm (Sus scrofa)
    - Transport of Mature mRNAs Derived from Intronless Transcripts (Sus scrofa)
      - Transport of Mature mRNA Derived from an Intronless Transcript (Sus scrofa)
        
        Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
      - Transport of the SLBP Dependant Mature mRNA (Sus scrofa)
        
        Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
      - Transport of the SLBP independent Mature mRNA (Sus scrofa)
        
        Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Translation (Sus scrofa)
  - Eukaryotic Translation Initiation (Sus scrofa)
    - Cap-dependent Translation Initiation (Sus scrofa)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Sus scrofa)
        
        Release of eIF4E from the inactive eIF4E:4E-BP complex (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        eIF4E:4E-BP [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Translation initiation complex formation (Sus scrofa)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
      - Ribosomal scanning and start codon recognition (Sus scrofa)
        
        Ribosomal scanning (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        Start codon recognition (Sus scrofa)
        
        48S complex [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Sus scrofa)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Sus scrofa)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Sus scrofa)
        
        eIF4F [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- MTOR signalling (Sus scrofa)
  - mTORC1-mediated signalling (Sus scrofa)
    - Dissociation of phosphorylated 4EBP1 from eIF4E (Sus scrofa)
      - EIF4E [cytosol] (Sus scrofa)
      - eIF4E:4E-BP1-P [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Sus scrofa)
      - eIF4E:4E-BP [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)
      - eIF4E:4E-BP1-P [cytosol] (Sus scrofa)
        
        EIF4E [cytosol] (Sus scrofa)