Reactome | RPL12 [cytosol]

RPL12 [cytosol]

Stable Identifier

R-SSC-72408

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPL12, A0A5G2QR46

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
- rRNA processing (Sus scrofa)
  - rRNA processing in the nucleus and cytosol (Sus scrofa)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Sus scrofa)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Translation (Sus scrofa)
  - Eukaryotic Translation Initiation (Sus scrofa)
    - Cap-dependent Translation Initiation (Sus scrofa)
      - Formation of a pool of free 40S subunits (Sus scrofa)
        
        Release of 40S and 60S subunits from the 80S ribosome (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Sus scrofa)
        
        The 60S subunit joins the translation initiation complex (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
        
        eIF5B:GTP is hydrolyzed and released (Sus scrofa)
        
        80S:Met-tRNAi:mRNA [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Sus scrofa)
      - Dissociation of L13a from the 60s ribosomal subunit (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
        
        60s ribosomal complex lacking L13a subunit [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
  - SRP-dependent cotranslational protein targeting to membrane (Sus scrofa)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Sus scrofa)
      - SRP:polypeptide+signal:ribosome [cytosol] (Sus scrofa)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        Homologues of RPL12 [cytosol] (Sus scrofa)
        
        RPL12 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QR46

Gene Names

RPL12

Reference Genes

ENSEMBL:ENSSSCG00000033019.3

Other Identifiers

414416

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0043226

GO:0070180

GO:1990904

Ssc.939.1.A1_at

Participates

as a member of

Homologues of RPL12 [cytosol] (Sus scrofa)

Inferred From

RPL12 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000197958

Ensembl

ENSSSCG00000033019, ENSSSCP00000065144, ENSSSCT00000080868

Cite Us!