Reactome | 26S proteasome [cytosol]

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G1/S DNA Damage Checkpoints (Sus scrofa)
    - p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
      - p53-Dependent G1 DNA Damage Response (Sus scrofa)
        
        Stabilization of p53 (Sus scrofa)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Sus scrofa)
        
        Proteasome mediated degradation of COP1 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - p53-Independent G1/S DNA damage checkpoint (Sus scrofa)
      - p53-Independent DNA Damage Response (Sus scrofa)
        
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Sus scrofa)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - M Phase (Sus scrofa)
    - Mitotic Metaphase and Anaphase (Sus scrofa)
      - Mitotic Anaphase (Sus scrofa)
        
        Separation of Sister Chromatids (Sus scrofa)
        
        Degradation of multiubiquitinated Securin (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Mitotic G2-G2/M phases (Sus scrofa)
    - G2/M Transition (Sus scrofa)
      - FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Sus scrofa)
        
        Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - The role of GTSE1 in G2/M progression after G2 checkpoint (Sus scrofa)
        
        GTSE1 facilitates proteasome-mediated degradation of TP53 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Regulation of mitotic cell cycle (Sus scrofa)
    - APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Sus scrofa)
        
        Degradation of multiubiquitinated cell cycle proteins (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
        
        APC/C:Cdc20 mediated degradation of Securin (Sus scrofa)
        
        Degradation of multiubiquitinated Securin (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Sus scrofa)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Sus scrofa)
        
        Degradation multiubiquitinated Cyclin A (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
        
        Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Ubiquitin-dependent degradation of Cyclin D (Sus scrofa)
      - Proteasome mediated degradation of Cyclin D1 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular response to chemical stress (Sus scrofa)
    - KEAP1-NFE2L2 pathway (Sus scrofa)
      - 26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Cellular response to hypoxia (Sus scrofa)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
      - Proteasome proteolyzes ub-HIF-alpha (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

DNA Replication (Sus scrofa)

- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
      - Ubiquitinated Cdc6 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Ubiquitinated Orc1 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional regulation by RUNX1 (Sus scrofa)
      - RUNX1 regulates transcription of genes involved in differentiation of HSCs (Sus scrofa)
        
        26S proteasome degrades TP73 polyubiquitinated by ITCH (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing-Cross presentation (Sus scrofa)
      - Cross-presentation of soluble exogenous antigens (endosomes) (Sus scrofa)
        
        Proteasomal clevage of exogenous antigen (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Proteasomal cleavage of substrate (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Signaling by the B Cell Receptor (BCR) (Sus scrofa)
    - Downstream signaling events of B Cell Receptor (BCR) (Sus scrofa)
      - Activation of NF-kappaB in B cells (Sus scrofa)
        
        Ubiquitinated IkB is degraded (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - TCR signaling (Sus scrofa)
    - Downstream TCR signaling (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - TNFR2 non-canonical NF-kB pathway (Sus scrofa)
    - 26Sproteasome degrades K48polyUb-NIK (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
    - NIK-->noncanonical NF-kB signaling (Sus scrofa)
      - 26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Protesomal degradation of K48polyUb-TRAF3 (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - C-type lectin receptors (CLRs) (Sus scrofa)
    - CLEC7A (Dectin-1) signaling (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - Dectin-1 mediated noncanonical NF-kB signaling (Sus scrofa)
        
        26S proteasome processes p-7S-p100:RELB to form p52:RELB (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated NF-kB activation (Sus scrofa)
      - 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Metabolism (Sus scrofa)

- Metabolism of amino acids and derivatives (Sus scrofa)
  - Metabolism of polyamines (Sus scrofa)
    - Regulation of ornithine decarboxylase (ODC) (Sus scrofa)
      - 26S proteosome degrades ODC holoenzyme complex (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Regulation of mRNA stability by proteins that bind AU-rich elements (Sus scrofa)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Sus scrofa)
    - AUF1:mRNA complex is destroyed (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - UCH proteinases (Sus scrofa)
      - ADRM1 binds 26S proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        ADRM1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - ADRM1:26S proteaseome binds UCHL5 (Sus scrofa)
        
        ADRM1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        ADRM1:26S proteasome:UCHL5 [cytosol] (Sus scrofa)
        
        ADRM1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Ub-specific processing proteases (Sus scrofa)
      - ADRM1:26S proteaseome binds USP14 (Sus scrofa)
        
        ADRM1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
        
        ADRM1:26S proteasome:USP14 [cytosol] (Sus scrofa)
        
        ADRM1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Neddylation (Sus scrofa)
    - 26S proteasome degrades HIFalpha (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
    - 26S proteasome degrades Ub-NFE2L2 (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
    - 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
      - NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - NEDD8 and UBD bind NUB1 and the 26S proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
      - NEDD8,UBD:NUB1:26S proteasome [cytosol] (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - ub UBXN7 is degraded by the 26S proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)

Signal Transduction (Sus scrofa)

- Intracellular signaling by second messengers (Sus scrofa)
  - PIP3 activates AKT signaling (Sus scrofa)
    - PTEN Regulation (Sus scrofa)
      - Regulation of PTEN stability and activity (Sus scrofa)
        
        Proteasome degrades polyubiquitinated PTEN (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - Regulation of RAS by GAPs (Sus scrofa)
        
        NF1 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - MAPK6/MAPK4 signaling (Sus scrofa)
    - MAPK6 is degraded by the 26S proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
- Signaling by Hedgehog (Sus scrofa)
  - Hedgehog 'off' state (Sus scrofa)
    - Degradation of GLI1 by the proteasome (Sus scrofa)
      - GLI1 is degraded by the proteasome after ubiquitination by ITCH (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - GLI3 is processed to GLI3R by the proteasome (Sus scrofa)
      - GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Hedgehog 'on' state (Sus scrofa)
    - ub-GLI is degraded by the proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
  - Hedgehog ligand biogenesis (Sus scrofa)
    - Hh C-terminal fragments are degraded by the proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
- Signaling by WNT (Sus scrofa)
  - Beta-catenin independent WNT signaling (Sus scrofa)
    - PCP/CE pathway (Sus scrofa)
      - Asymmetric localization of PCP proteins (Sus scrofa)
        
        PRICKLE1 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
  - Degradation of beta-catenin by the destruction complex (Sus scrofa)
    - Degradation of ubiquitinated beta catenin by the proteasome (Sus scrofa)
      - 26S proteasome [cytosol] (Sus scrofa)
  - TCF dependent signaling in response to WNT (Sus scrofa)
    - Degradation of AXIN (Sus scrofa)
      - Ub-RibC-AXIN is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - Ubiquitinated AXIN is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
    - Degradation of DVL (Sus scrofa)
      - Ubiquitinated DVL is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)
      - Ubiquitinated DVL1 is degraded by the proteasome (Sus scrofa)
        
        26S proteasome [cytosol] (Sus scrofa)

Transport of small molecules (Sus scrofa)

- ABC-family proteins mediated transport (Sus scrofa)
  - misfolded CFTR is degraded by the 26S proteasome (Sus scrofa)
    - 26S proteasome [cytosol] (Sus scrofa)