Reactome | POLD4 [nucleoplasm]

Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - DNA strand elongation (Sus scrofa)
        
        Lagging Strand Synthesis (Sus scrofa)
        
        Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive synthesis on the lagging strand (Sus scrofa)
        
        Formation of Okazaki fragments (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate (Sus scrofa)
        
        RPA binds to the Flap (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Recruitment of Dna2 endonuclease (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Leading Strand Synthesis (Sus scrofa)
        
        Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
- Chromosome Maintenance (Sus scrofa)
  - Telomere Maintenance (Sus scrofa)
    - Extension of Telomeres (Sus scrofa)
      - Telomere C-strand (Lagging Strand) Synthesis (Sus scrofa)
        
        Disassociation of Processive Complex and Completed Telomere End (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Polymerase switching on the C-strand of the telomere (Sus scrofa)
        
        Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive synthesis on the C-strand of the telomere (Sus scrofa)
        
        Formation of C-strand Okazaki fragments (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate on the C-strand (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Joining of adjacent Okazaki fragments of the C-strand (Sus scrofa)
        
        Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate from the C-strand (Sus scrofa)
        
        RPA binds to the Flap on the C-strand (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Recruitment of DNA2 endonuclease to the C strand (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap from the C-strand (Sus scrofa)
        
        Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- Base Excision Repair (Sus scrofa)
  - Resolution of Abasic Sites (AP sites) (Sus scrofa)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
      - PCNA-Dependent Long Patch Base Excision Repair (Sus scrofa)
        
        LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
- DNA Damage Bypass (Sus scrofa)
  - Recognition of DNA damage by PCNA-containing replication complex (Sus scrofa)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)
      - POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Sus scrofa)
    - Termination of translesion DNA synthesis (Sus scrofa)
      - POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - HDR through Homologous Recombination (HRR) (Sus scrofa)
        
        D-loop extension by DNA polymerases (Sus scrofa)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
- Mismatch Repair (Sus scrofa)
  - Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Sus scrofa)
    - DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)
      - DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
  - Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Sus scrofa)
    - DNA polymerase delta polymerizes DNA across single stranded gap (Sus scrofa)
      - DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
- Nucleotide Excision Repair (Sus scrofa)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
    - Dual Incision in GG-NER (Sus scrofa)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE,POLK [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
    - Dual incision in TC-NER (Sus scrofa)
      - 3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)
        
        POLD,POLE,POLK [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- Synthesis of DNA (Sus scrofa)
  - DNA strand elongation (Sus scrofa)
    - Lagging Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
      - Processive synthesis on the lagging strand (Sus scrofa)
        
        Formation of Okazaki fragments (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Formation of the Flap Intermediate (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of the Flap Intermediate (Sus scrofa)
        
        RPA binds to the Flap (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Recruitment of Dna2 endonuclease (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment:Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragment complex [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Removal of remaining Flap (Sus scrofa)
        
        Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
    - Leading Strand Synthesis (Sus scrofa)
      - Polymerase switching (Sus scrofa)
        
        Formation of Processive Complex (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)
        
        Processive complex [nucleoplasm] (Sus scrofa)
        
        DNA Polymerase delta tetramer [nucleoplasm] (Sus scrofa)
        
        POLD4 [nucleoplasm] (Sus scrofa)